Results 51 to 60 of about 4,034 (217)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Is Heidegger’s “Turn” a Realist Project? [PDF]
Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2014 In this essay I consider the relationship between Heidegger’s famous “turn” (Kehre) and realism. I begin with Heidegger’s critique of the problem of an external world, and I describe how this critique anticipates New Realism.
Markus Gabriel
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Granice poznania a spór między realizmem i antyrealizmem (COGNITIVE LIMITS AND THE REALISM/ANTI-REALISM DEBATE) [PDF]
Analiza i Egzystencja, 2006 According to metaphysical realism, there are truths that we can understand but cannot even in principle come to know, whereas according to anti-realism, there are no such truths.
Sven Rosenkranz
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Historicidad, Realismo y Verdad
Principia: An International Journal of Epistemology, 2017 This paper argues that the historical character of our knowledge is compatible with both ontological and epistemological realism. The first part critically analyses the thesis according to which the situated nature of our cognitive practices implies that
Carlos Miguel Gómez Rincon
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Er(r)go, 2001 Grzegorz Trela – Towards anti-antirealism Artykuł poświęcony kontrowersji dzielącej metdologów nauki w kontekście sporu "realizm-antyrealizm".
Grzegorz Trela
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Christine Baron e Manfed Engel (Eds.), Realism/Anti-Realism in 20th Century Literature
Between, 2012 Parte della serie «Internationale Forschungen zur Allgemeinen und Vergleichenden Literaturwissenschaft» edita da Rodopi, il volume è composto da quattordici saggi, cinque dei quali in francese, i restanti in inglese. Come chiarisce sin dalle prime righe
Gianluigi Rossini
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