Results 71 to 80 of about 12,098 (310)
How to solve the knowability paradox with transcendental epistemology [PDF]
, 2018 A novel solution to the knowability paradox is proposed based on Kant’s transcendental epistemology. The ‘paradox’ refers to a simple argument from the moderate claim that all truths are knowable to the extreme claim that all truths are known.
Stephenson, Andrew
core +1 more source
Is Heidegger’s “Turn” a Realist Project? [PDF]
Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2014 In this essay I consider the relationship between Heidegger’s famous “turn” (Kehre) and realism. I begin with Heidegger’s critique of the problem of an external world, and I describe how this critique anticipates New Realism.
Markus Gabriel
doaj
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Moral Realism and Anti-Realism outside the West: A Meta-Ethical Turn in Buddhist Ethics [PDF]
, 2013 In recent years, discussions of Buddhist ethics have increasingly drawn upon the concepts and tools of modern ethical theory, not only to compare Buddhist perspectives with Western moral theories, but also to assess the meta-ethical implications of ...
Davis, Gordon Fraser
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Granice poznania a spór między realizmem i antyrealizmem (COGNITIVE LIMITS AND THE REALISM/ANTI-REALISM DEBATE) [PDF]
Analiza i Egzystencja, 2006 According to metaphysical realism, there are truths that we can understand but cannot even in principle come to know, whereas according to anti-realism, there are no such truths.
Sven Rosenkranz
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Why Quantum Theory is Possibly Wrong [PDF]
, 2010 Quantum theory is a tremendously successful physical theory, but nevertheless suffers from two serious problems: the measurement problem and the problem of interpretational underdetermination.
B.D. Espagnat +7 more
core +3 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Historicidad, Realismo y Verdad
Principia: An International Journal of Epistemology, 2017 This paper argues that the historical character of our knowledge is compatible with both ontological and epistemological realism. The first part critically analyses the thesis according to which the situated nature of our cognitive practices implies that
Carlos Miguel Gómez Rincon
doaj +1 more source