Results 21 to 30 of about 70,195 (211)

Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity. [PDF]

, 2017
BackgroundProdrug-activator gene therapy with Toca 511, a tumor-selective retroviral replicating vector (RRV) encoding yeast cytosine deaminase, is being evaluated in recurrent high-grade glioma patients.
Gruber, Harry E, Hacke, Katrin, Hiraoka, Kei, Huang, Tiffany T, Inagaki, Akihito, Jolly, Douglas J, Kamijima, Shuichi, Kasahara, Noriyuki, Kato, Yuki, Kruse, Carol A, Matsumoto, Hiroshi, Mitchell, Leah A, Ostertag, Derek, Robbins, Joan M, Takahashi, Masamichi   +14 more
core   +1 more source

Bilateral lower limb gangrene due to HIV vasculitis – a rare case

Sri Lankan Journal of Infectious Diseases, 2017
Human immunodeficiency virus (HIV) positive patients may develop vasculitis, either mediated by immunological factors or by direct vascular injury. It may also be caused by infectious agents or by some nonspecific causes.
D. Majumdar, S. Chakraborty, S. Pandey, S. Bhattacharya, B. Bhattacharjee, A. Naskar, B. Saha   +6 more
doaj   +1 more source

Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model. [PDF]

, 2017
BackgroundToca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding an optimized yeast cytosine deaminase (CD). Tumor-selective expression of CD converts the prodrug, 5-fluorocytosine (5-FC), into the active chemotherapeutic, 5 ...
Gruber, Harry E, Hiraoka, Kei, Inagaki, Akihito, Jolly, Douglas J, Kasahara, Noriyuki, Kato, Yuki, Lopez Espinoza, Fernando, Mendoza, Daniel, Mitchell, Leah A, Robbins, Joan M   +9 more
core   +1 more source

Patentes farmacêuticas e saúde pública: desafios à política brasileira de acesso ao tratamento anti-retroviral Pharmaceutical patents and public health: challenges for the Brazilian antiretroviral treatment policy

Cadernos de Saúde Pública, 2008
O preço elevado de medicamentos patenteados tem intensificado o debate em torno do impacto do regime da propriedade intelectual sobre o acesso a tratamentos de saúde, merecendo destaque o caso do HIV/AIDS.
Constance Marie Milward de Azevedo Meiners
doaj   +1 more source

Cost variation analysis of various brands of anti-retroviral agents currently available in Indian market: an economic perspective study

International Journal of Basic & Clinical Pharmacology, 2022
Background: The aim was to analyze the percentage cost variations among different brands of the commonly prescribed anti-retroviral agents in the treatment of human immunodeficiency virus.Methods: The cost of different brands of commonly used Anti-Retroviral agents was sorted out by referring latest Indian drug index online, drug today, current index ...
Anusha R., Geetha A.
openaire   +1 more source

Recent Progress in Synthesis, POM Analyses and SAR of Coumarin-Hybrids as Potential Anti-HIV Agents—A Mini Review

Pharmaceuticals, 2023
The human immunodeficiency virus (HIV) is the primary cause of acquired immune deficiency syndrome (AIDS), one of the deadliest pandemic diseases. Various mechanisms and procedures have been pursued to synthesise several anti-HIV agents, but due to the ...
Mustapha Suleiman, Faisal A. Almalki, Taibi Ben Hadda, Sarkar M. A. Kawsar, Subhash Chander, Sankaranarayanan Murugesan, Ajmal R. Bhat, Andrey Bogoyavlenskiy, Joazaizulfazli Jamalis   +8 more
doaj   +1 more source

Interventions for neurocognitive dysfunction [PDF]

, 2017
Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core   +2 more sources

Profile of anti-retroviral agents use in Colombia

Biomédica, 2018
Introducción. La infección por VIH es una pandemia para la que actualmente existe tratamiento farmacológico que puede controlarla y prolongar la expectativa de vida del paciente.Objetivo. Determinar los patrones de prescripción de fármacos antirretrovirales en una población de personas afiliadas al régimen contributivo del Sistema General de Seguridad ...
Machado-Alba, Jorge E., Atehortúa-Otero, Miguel A., Cortés-Mejía, Diego A.   +2 more
openaire   +5 more sources

Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Assfalg-Machleidt, Irmgard, Helm, K. von der, Hoffmann, D., Koszinowski, U., Machleidt, Werner, Nitschko, H.   +5 more
core   +1 more source

A longitudinal evaluation of the impact of a polylactic acid injection therapy on health related quality of life amongst HIV patients treated with anti-retroviral agents under real conditions of use [PDF]

BMC Infectious Diseases, 2013
Many HIV patients receiving antiretroviral treatment develop lipodystrophy. NEW-FILL® is a polylactic acid injected to treat facial lipoatrophy. The objectives of this study were to describe (1) change in quality of life (QoL) of HIV patients treated with NEW-FILL® in the management of facial lipoatrophy; (2) efficacy of NEW-FILL® using facial ...
Duracinsky, Martin, Leclercq, Pascale, Armstrong, Andrew Richard, Dolivo, Marc, Mouly, Frédéric, Chassany, Olivier   +5 more
openaire   +2 more sources