Results 201 to 210 of about 581,138 (251)
Acoziborole resistance associated mutations in trypanosome CPSF3
Ridgway M +6 more
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Veterinary Parasitology, 2021
Trypanosoma evansi is an extracellular flagellate blood protozoan parasite and an etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and have been used for the treatment of animal trypanosomosis, but they show severe toxic effects and also face the problem of drug resistance.
R. Rani +3 more
semanticscholar +3 more sources
Trypanosoma evansi is an extracellular flagellate blood protozoan parasite and an etiological agent of animal trypanosomosis. Presently, only a few drugs are registered and have been used for the treatment of animal trypanosomosis, but they show severe toxic effects and also face the problem of drug resistance.
R. Rani +3 more
semanticscholar +3 more sources
European Journal of Organic Chemistry, 2022
AbstractA series of L‐lyxo and L‐xylo‐ pentofuranose‐mimetic iminosugars and derivatives were efficiently synthesized in a stereoselective manner, through a concise strategy which involves an organocatalyzed Mannich reaction of an imine and a protected dioxanone as key step, using D‐proline as catalyst.
J. M. Mesa +3 more
semanticscholar +2 more sources
AbstractA series of L‐lyxo and L‐xylo‐ pentofuranose‐mimetic iminosugars and derivatives were efficiently synthesized in a stereoselective manner, through a concise strategy which involves an organocatalyzed Mannich reaction of an imine and a protected dioxanone as key step, using D‐proline as catalyst.
J. M. Mesa +3 more
semanticscholar +2 more sources
Bioorganic & Medicinal Chemistry Letters, 2021
Trypanosoma brucei parasites cause Human African Trypanosomiasis and the current drugs for its treatment are often inefficient and toxic. This urges the need to development of new antitrypanosomal agents. We report the synthesis and biological profiling of 3'-deoxy-3'-fluororibonucleosides derived from 7-deazaadenine nucleosides bearing diverse ...
Van Hai Nguyen +9 more
semanticscholar +3 more sources
Trypanosoma brucei parasites cause Human African Trypanosomiasis and the current drugs for its treatment are often inefficient and toxic. This urges the need to development of new antitrypanosomal agents. We report the synthesis and biological profiling of 3'-deoxy-3'-fluororibonucleosides derived from 7-deazaadenine nucleosides bearing diverse ...
Van Hai Nguyen +9 more
semanticscholar +3 more sources
Polycyclic aromatic compounds (Print), 2022
Sulfonamide-based carboxamide drugs have multiple active sites that confers them with a variety of chemical and pharmacological activities. The combination of structural functionalities has been established to be vital in the drug discovery process.
Fredrick C. Asogwa +10 more
semanticscholar +1 more source
Sulfonamide-based carboxamide drugs have multiple active sites that confers them with a variety of chemical and pharmacological activities. The combination of structural functionalities has been established to be vital in the drug discovery process.
Fredrick C. Asogwa +10 more
semanticscholar +1 more source
Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima.
Fitoterapia, 2017In previous studies the aerial parts of Achillea fragrantissima were found to have substantial antileishmanial and antitrypanosomal activity. A bioassay-guided fractionation of a dichloromethane extract yielded the isolation of the essential anti-trypanosomal compounds of the plant. Seven sesquiterpene lactones (including Achillolide-A), two flavonoids,
Joseph Skaf +5 more
semanticscholar +3 more sources
In vitro anti-trypanosomal activity of Morinda lucida leaves
AFRICAN JOURNAL OF BIOTECHNOLOGY, 2012 Bioassay-guided fractionation of the crude methanol extract of Morinda lucida Benth. (Rubiaceae) was carried out by column chromatography and anti-trypanosomal activity was tested using in vitro cultures of Trypanosoma brucei brucei S427. Three active fractions (ML 13-18, ML 19-28 and ML 33-45) were obtained with minimum inhibitory concentration (MIC ...
N. Nweze
semanticscholar +2 more sources