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Anti-Trypanosomal Activity of Diarylheptanoids Isolated from the Bark ofAlnus japonica
The American Journal of Chinese Medicine, 2014The crude extract of Alnus japonica bark exhibited a strong effect on the growth of Trypanosoma brucei. Subsequent chromatographic separation resulted in the isolation of two novel diarylheptanoids, known as alnuside C (2) and alnuside D (3), and three known compounds, 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptan-3(R)-O-β-D-glucopyranoside (1 ...
Nguyen Huu, Tung +14 more
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Org. Biomol. Chem., 2014
An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group.
William, Doherty +6 more
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An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group.
William, Doherty +6 more
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Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiophen-4,9-quinones
Bioorganic & Medicinal Chemistry, 1997Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts reaction and tandem-lithiation of aromatic diethylamides. These quinones were evaluated for their trypanocidal and anti-plasmodial activities by their effects on: (1) growth of epimastigote forms of Trypanosoma cruzi in vitro, (2) lysis of trypomastigote ...
Zani, Carlos L. +6 more
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Bioorganic & Medicinal Chemistry, 2013
Iron is an essential growth component in all living organisms and plays a central role in numerous biochemical processes due to its redox potential and high affinity for oxygen. The use of iron chelators has been suggested as a novel therapeutic approach towards parasitic infections, such as malaria, sleeping sickness and leishmaniasis.
Gehrke, Sebastian S +6 more
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Iron is an essential growth component in all living organisms and plays a central role in numerous biochemical processes due to its redox potential and high affinity for oxygen. The use of iron chelators has been suggested as a novel therapeutic approach towards parasitic infections, such as malaria, sleeping sickness and leishmaniasis.
Gehrke, Sebastian S +6 more
openaire +3 more sources
Synthesis and Anti-Trypanosomal Activity of Various 8-Aza-7-deaza-5‘-noraristeromycin Derivatives
Journal of Medicinal Chemistry, 1997A recent observation that (+)-7-deaza-5'-noraristeromycin (1), as an L-like analogue of aristeromycin, possessed meaningful anti-trypanosomal properties has prompted a search of other 7-deazapurines with similar or improved anti-trypanosomal responses. In that direction a series of pyrazolo[3,4-d]pyrimidines (that is, 8-aza-7-deaza-5'-noraristeromycin ...
K L, Seley +4 more
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Anti-trypanosomal activity of natural medicines
Parasitology International, 1998F. Kiuchi +4 more
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American Cancer Society nutrition and physical activity guideline for cancer survivors
Ca-A Cancer Journal for Clinicians, 2022Cheryl L Rock +2 more
exaly
American Cancer Society guideline for diet and physical activity for cancer prevention
Ca-A Cancer Journal for Clinicians, 2020Cheryl L Rock +2 more
exaly
Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
exaly