Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Comprehensive Phytochemical Profiling and Multi-Target Biological Evaluation of <i>Hibiscus sabdariffa</i> L. Calyx Extracts From Libya: A Promising Functional Food Candidate With Antibacterial, Antioxidant, Anti-Inflammatory, and Cytotoxic Properties: Validation Through In Silico Approaches. [PDF]
Kabbashi AS +8 more
europepmc +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Mucosal Immune Responses in People Living with HIV May Confer Protection from SARS-CoV-2 Infections After COVID-19 Vaccination. [PDF]
Judith A +7 more
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Species Accumulation Stabilizes the Synchronous Responses to the Environment of Vertebrate Communities Worldwide. [PDF]
Picó S, Almaraz P, Godoy O.
europepmc +1 more source
Detection of anti-<i>Mycoplasma bovis</i> IgG in bovine nasopharyngeal swabs. [PDF]
Dudley EP, Hunt BO, Valeris-Chacin R.
europepmc +1 more source
Efficacy of belimumab in patients with SLE and haematological manifestations: retrospective analysis from the BeRLiSS 2.0 cohort. [PDF]
Hulej G +42 more
europepmc +1 more source
Recent advances in thiazole-based derivatives targeting diverse anti-inflammatory pathways. [PDF]
Dawood DH +4 more
europepmc +1 more source

