Results 241 to 250 of about 7,382,706 (304)

Proteomic profiling reveals treatment-dependent inflammatory signatures and identifies biomarkers of refractory age-related macular degeneration. [PDF]

Front Pharmacol
Eandi CM, Borgo A, de Oliveira Figueiredo E, de Haro D, Kaufmann DE, Roduit R.   +5 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells-Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage. [PDF]

J Neurochem
Mutti V, Bono F, Tomasoni Z, Fadel D, Gnutti C, Sbrini G, Gaudenzi C, Salvi V, Bosisio D, Russo I, Bolognin S, Schwamborn JC, Missale C, Fiorentini C.   +13 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Longitudinal changes of serum immunoglobulins under ocrelizumab: factors associated with hypogammaglobulinemia and infection risk in a real-world multiple sclerosis cohort. [PDF]

Neurol Res Pract
Bohn A, Teubner FS, Tauber SC, Waschbisch A.   +3 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Targeting pyruvate kinase M2 (PKM2) reduces T cell pathogenicity in multiple sclerosis. [PDF]

EBioMedicine
Ellmeier E, Schnabl A, Meissel J, Stracke A, Rittchen S, Stöger L, Passegger CA, Schwarzl L, Tafrali C, Demjaha R, Martinez-Serrat M, Kaiser T, Zeiler LC, Seifried K, Topler A, Klemen I, Heschl B, Damulina A, Runtsch MC, Fessler J, Hofer E, Khalil M, Angiari S.   +22 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

'Far right just means anyone who wants to support British values': Mobilizing 'British values' talk in discussions of the August 2024 UK race riots. [PDF]

Br J Soc Psychol
Sambaraju R, Kirkwood S.
europepmc   +1 more source