Results 111 to 120 of about 2,249,117 (300)

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Synergistic effects of traditional Chinese medicine and anti-VEGF therapy on diabetic retinopathy progression: Insights into pharmacological mechanisms and clinical outcomes

Pakistan Journal of Pharmaceutical Sciences
This study investigated the effects of combining traditional Chinese medicine (TCM) with anti-VEGF therapy in diabetic retinopathy (DR) and diabetic macular edema (DME). A total of 119 cases with DME were divided into the anti-VEGF treatment group (n=56)
Xianlin Zhou, Lin Kong, Qihong Wu
doaj   +1 more source

Vascular Endothelial Growth Factors: Pharmacological aspects and applications in ophthalmic practices

Delhi Journal of Ophthalmology, 2013
Vascular endothelial growth factor (VEGF) plays a critical role in initiating a cascade of reactions important for the normal as well as abnormal angiogenesis.
Ashok K Dubey, N R Biswas, G K Das
doaj   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Immunohistochemical Localization of VEGF and VEGF Receptors in Developing Human Tooth Germ [PDF]

, 2007
P(論文)Vascular endothelial growth factor (VEGF) is a major angiogenetic factor in both developmental and wound healing processes. Recent studies have shown the expression of VEGF mRNA in lung, kidney, heart, ovary and various organs.
中川, 敏浩, 安部, 仁晴, NAKAGAWAC, Toshihiro, 9920, 9921, ツクダ, ヒデオ, AMBE, Kimiharu, ナカガワ, トシヒロ, 9919, 月田, 秀夫, TSUKIDA, Hideo, 9922, アベ, キミハル, 9923, 9917, 9918, 9915, 9916   +17 more
core  

Anti-VEGF antibody did not influence mean alveolar space area.

, 2016
The mean alveolar space area was without significant differences between these six groups (all p>0.05). Anti-VEGF antibody, anti-vascular endothelial growth factor antibody; IR, ischemia-reperfusion; ALI, acute lung injury.
Chou-Chin Lan (2938674), Chin-Pyng Wu (724102), Shu-Yu Wu (129447), Kun-Lun Huang (456586), Shih-En Tang (2938668), Chung-Kan Peng (2938671)   +5 more
core   +1 more source

Optical coherence tomography angiography findings in patients with branch retinal vein occlusion treated with Anti-VEGF

, 2020
Purpose: To investigate retinal microvasculature changes in patients treated with anti-VEGF for macular edema secondary to branch retinal vein occlusion. Methods: We examined 38 eyes of 19 patients for the study.
Neşe Çetin Dogan (8047940), Emine Ciloglu (8047937)   +1 more
core   +1 more source

Evaluation of microaneurysms as predictors of therapeutic response to anti-VEGF therapy in patients with DME

PLoS ONE, 2022
Administration of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the first-line therapy for diabetic macular oedema (DME). However, some patients show no or insufficient response to repeated anti-VEGF injections.
Makoto Hatano, Fumiaki Higashijima, Takuya Yoshimoto, Tadahiko Ogata, Manami Ohta, Yuka Kobayashi, Makiko Wakuta, Ryoji Yanai, Kazuhiro Kimura   +8 more
doaj  

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source