Results 111 to 120 of about 268,104 (311)

Efficacy and Tolerability of First-Line Anti-eGFR and Anti-VEGF Therapy in Elderly Patients with Ras-Wild Metastatic Colon Cancer

İstanbul Medical Journal
Introduction: Adding targeted agents to chemotherapy for metastatic colorectal cancer increases survival. There have been no clinical trials in older populations comparing the efficacy of the targeted agents.
Ender Doğan, Sedat Tarık Fırat, Murat Eser, Oktay Bozkurt, Mevlüde İnanç, Metin Özkan   +5 more
doaj   +1 more source

Vascular Endothelial Growth Factors: Pharmacological aspects and applications in ophthalmic practices

Delhi Journal of Ophthalmology, 2013
Vascular endothelial growth factor (VEGF) plays a critical role in initiating a cascade of reactions important for the normal as well as abnormal angiogenesis.
Ashok K Dubey, N R Biswas, G K Das
doaj   +1 more source

Interleukin-17A promotes parietal cell atrophy by inducing apoptosis [PDF]

, 2018
Background & Aims: Atrophic gastritis caused by chronic inflammation in the gastric mucosa leads to the loss of gastric glandular cells, including acid-secreting parietal cells.
Alderuccio, Burclaff, Buzzelli, Caruso, Correa, Correa, Correa, Dai, Degterev, DeLyria, Ding, DiPaolo, DiPaolo, El-Omar, Ferlay, Fox, Ge, Harrington, Hervas-Stubbs, Howlett, Kolls, Landgren, Lennerz, Li, Liao, Machado, McHugh, Merchant, Mills, Moseley, Nam, Nguyen, Nguyen, Nguyen, Nguyen, Onishi, Park, Ramsey, Schumacher, Schwarzenberger, Stummvoll, Varga, Velin, Wada, Yamada, Yamaguchi, Zhang, Zhu   +47 more
core   +3 more sources

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Bevacizumab radioimmunotherapy (RIT) with accelerated blood clearance using the avidin chase [PDF]

, 2018
学位記番号 ...
RYAN, YUDISTIRO, リアン, ユディスティロ   +1 more
core  

Thromboembolic events in patients treated with anti-angiogenic drugs [PDF]

, 2010
Induction of neo-angiogenesis is a fundamental step in many pathological conditions. The therapeutic value of inhibiting angiogenesis is an interesting area of research in oncology, with vascular endothelial growth factor (VEGF) being the most suitable ...
Ferroni, P, Formica, V, Guadagni, F, Roselli, M   +3 more
core   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations. [PDF]

, 2013
Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma.
Angelo, Laura S, Kurzrock, Razelle, Schroeder, Rebecca Dunbar   +2 more
core   +3 more sources

Bifunctional Surfaces With Immobilized Antibodies and Bioactive Peptides Mediate Selective Capture and Proliferation of Endothelial Colony‐Forming Cells

Advanced Healthcare Materials, EarlyView.
A tunable bifunctional surface is developed by combining Fc‐binding peptides and RGD motifs to present oriented antibodies alongside integrin‐mediated signaling. The platform selectively captures endothelial colony‐forming cells while promoting their adhesion and proliferation.
Hugo A. Level, Marc‐Antoine Campeau, Mohamed A. Elkhodiry, Gaétan Laroche, Jean‐François Tanguay, Corinne A. Hoesli   +5 more
wiley   +1 more source

Metformin: a modulator of bevacizumab activity in cancer? A case report. [PDF]

, 2015
Recurrent type I endometrial cancer ((EC)) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody, has shown clinical activity in this setting. To our knowledge, however, although some diabetic
Aliberti, C, Casarin, A, Indraccolo, Stefano, Nardin, M, Nicoletto, Mo, Pomerri, Fabio, Randon, G, Zulato, E   +7 more
core   +1 more source