Results 41 to 50 of about 244,949 (162)

Pazopanib and anti-VEGF therapy

Research and Reports in Urology, 2010
Pazopanib (Votrient™, GlaxoSmithKline), a multi-kinase inhibitor with activity against VEGFR and other receptors, was recently approved by the FDA for the treatment of advanced renal cell carcinoma (RCC). Here, we review the history of its development, together with an overview of VEGF and its receptors and co-receptors.
openaire   +3 more sources

In vitro analysis of VEGF-mediated endothelial permeability and the potential therapeutic role of Anti-VEGF in severe dengue

Biochemistry and Biophysics Reports
Background: Vascular endothelial growth factor (VEGF) is one of the proteins involved in dengue immunopathogenesis. It is overexpressed in severe dengue and contributes to vascular permeability and plasma leakage.
Sheng Jye Lim, Seng Chiew Gan, Hooi Tin Ong, Yun Fong Ngeow   +3 more
doaj   +1 more source

Efficacy and effectiveness of anti-VEGF or steroids monotherapy versus combination treatment for macular edema secondary to retinal vein occlusion: a systematic review and meta-analysis

BMC Ophthalmology, 2022
Background Retinal vein occlusion (RVO) is the main cause of retinal vascular blindness. Laser photocoagulation therapy is the regarded as the standard treatment for branch retinal vein occlusion (BRVO) in the guidelines, but it is not effective for ...
Wuyue Zhang, Yuan Liu, Aimin Sang
doaj   +1 more source

Comparative outcomes of pars plana vitrectomy with subretinal rt-PA injection in polypoidal choroidal vasculopathy: the role of simultaneous anti-VEGF treatment

Frontiers in Medicine
PurposeThis study aimed to assess the efficacy of simultaneous intravitreal anti-vascular endothelial growth factor (VEGF) with pars plana vitrectomy (PPV), subretinal recombinant tissue plasminogen activator (rt-PA), and pneumatic tamponade in treating ...
Lulu Chen, Lulu Chen, Chuting Wang, Chuting Wang, Wenfei Zhang, Wenfei Zhang, Lihui Meng, Lihui Meng, Lu Sun, Lu Sun, Youxin Chen, Youxin Chen   +11 more
doaj   +1 more source

EORTC Receptor and Biomarker Study Group Report: A Sandwich Enzyme-Linked Immunosorbent Assay for Vascular Endothelial Growth Factor in Blood and Tumor Tissue Extracts

The International Journal of Biological Markers, 2000
A four-antibody sandwich enzyme-linked immunosorbent assay (ELISA) for vascular endothelial growth factor (VEGF) for application in blood (serum and plasma) and tumor tissue extracts was set up within the framework of the EORTC Receptor and Biomarker ...
P.N. Span, N. Grebenchtchikov, J. Geurts-Moespot, J.R. Westphal, A.M.J. Lucassen, C.G.J. Sweep   +5 more
doaj   +1 more source

Topical bromfenac in VEGF-driven maculopathies: topical review and meta-analysis

BMC Ophthalmology
Background Topical non-steroidal anti-inflammatory drugs have the potential to reduce treatment burden and improve outcomes of anti-VEGF therapy for a number of retinal disorders, including neovascular age-related macular degeneration, diabetic macular ...
Alexei N. Kulikov, Alexander S. Vasiliev, Yana A. Kalinicheva, Dmitrii S. Maltsev   +3 more
doaj   +1 more source

Limited Immune-Mediated Efficacy of Anti-PD-L1/VEGF in EGFR-TKI-Naïve Egfr-Mutant Lung Cancer with Non-Inflamed Tumor Microenvironment

Current Oncology
Immune checkpoint inhibitors (ICIs) show limited efficacy in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma due to its non-inflamed tumor microenvironment (TME).
Atsuko Hirabae, Tadahiro Kuribayashi, Shuta Tomida, Sachi Okawa, Takamasa Nakasuka, Kazuya Nishii, Jun Nishimura, Go Makimoto, Kiichiro Ninomiya, Hisao Higo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masamichi Sugimoto, Yosuke Togashi, Yoshinobu Maeda, Katsuyuki Kiura, Kadoaki Ohashi   +17 more
doaj   +1 more source

Anti-VEGF and Beyond [PDF]

Journal of Ophthalmology, 2017
T. Bertelmann, H. Kaymak, F. T. A. Kretz, M. J. Koss   +3 more
openaire   +3 more sources

The matricellular protein CCN5 prevents anti-VEGF drug-induced epithelial-mesenchymal transition of retinal pigment epithelium

Scientific Reports
Age-related macular degeneration (AMD) is one of the major causes of blindness in the elderly worldwide. Anti-vascular endothelial growth factor (VEGF) drugs have been widely used to treat the neovascular type of AMD (nAMD).
Sora Im, Min Ho Song, Muthukumar Elangovan, Kee Min Woo, Woo Jin Park   +4 more
doaj   +1 more source

LASER PHOTOCOAGULATION VERSUS INTRAVITREAL ANTI VEGF AGENTS FOR TREATMENT OF RETINOPATHY OF PREMATURITY [PDF]

Egyptian Journal of Clinical Ophthalmology
Background: Early birth and various oxygen techniques can cause retinopathy of prematurity(ROP), a widespread childhood visual problem. An aggressive ROP (A-ROP) differs from normalprogression. Diode laser replaced cryotherapy.
Aldghaimy, A.
doaj   +1 more source