Results 51 to 60 of about 2,389,723 (301)

Current perspectives on the use of anti-VEGF drugs as adjuvant therapy in glaucoma [PDF]

, 2016
The approval of one of the first anti-vascular endothelial growth factor (VEGF) agents for the treatment of neovascular age-related macular degeneration one decade ago marked the beginning of a new era in the management of several sight-threatening ...
Morales-Fernández, L., Polo Llorens, V., Perucho González, Lucía, Herrero Vanrell, María Del Rocío, García-Feijoo, Julián, Pablo Júlvez, Luis, Martínez-de-la-Casa, José María, Polo Llorens, Vicente, García-Feijoo, J., Andrés-Guerrero, V., Perucho-González, L., Konstas, A.G P., Martínez De La Casa Fernández-Borrella, José María, Morales-Fernández, Laura, Júlvez, Luis Pablo, Andrés Guerrero, Vanesa, García Feijoo, Julián, Saenz-Francés, Federico, Pablo Júlvez, L., Perucho-González, Lucía, Konstas, Anastasios Georgios P., Herrero-Vanrell, R., Martínez-de-la-Casa, J.M., Andrés-Guerrero, Vanessa, Morales Fernández, Laura, Sáenz Francés, Federico, Llorens, Vicente Polo, Konstas, Anastasios-Georgios, Herrero-Vanrell, Rocío, Saenz-Francés, F.   +29 more
core   +1 more source

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia [PDF]

, 2003
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately ...
Shima, D., Christiana Ruhrberg, Betsholtz, C, Jeltsch, M, Abramsson, A., Shima, D, Matthew Golding, Lundkvist, A, Lundkvist, A., Golding, M, David Shima, Ruhrberg, C, Christopher Mitchell, Mitchell, C, Betsholtz, C., Kari Alitalo, Gerhardt, H, Ruhrberg, C., Christer Betsholtz, Golding, M., Jeltsch, M., Holger Gerhardt, Abramsson, A, Alitalo, K, Andrea Lundkvist, Fruttiger, M., Gerhardt, H., Alitalo, K., Alexandra Abramsson, Mitchell, C., Fruttiger, M, Michael Jeltsch, Marcus Fruttiger   +32 more
core   +1 more source

CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance

, 2021
Despite wide use of anti-vascular endothelial growth factor (VEGF) therapy for many solid cancers, most individuals become resistant to this therapy, leading to disease progression.
Bayaktar, Emine, McGuire, Michael H, Jennings, Nicholas B, Ma, Shaolin, Hu, Wen, Mangala, Lingegowda S, Rodland, Karin D, Lee, Sanghoon, Hu, Wei, Coleman, Robert L, Ram, Prahlad T, Yokoi, Akira, Piehowski, Paul D, Pradeep, Sunila, Liu, Tao, Ramakrishnan, Sundaram, Lopez-Berestein, Gabriel, Villar-Prados, Alejandro, LaFargue, Christopher J, Rodriguez-Aguayo, Cristian, Sood, Anil K, Wu, Sherry Y, Kundra, Vikas, Lara, Olivia D, Sunila Pradeep, Paul D. Piehowski, Wei Hu, Prahlad T. Ram, Gabriel Lopez-Berestein, Vikas Kundra, Sundaram Ramakrishnan, Shaolin Ma, Emine Bayaktar, Nicholas B. Jennings, Cristian Rodriguez-Aguayo, Alejandro Villar-Prados, Michael H. McGuire, Robert L. Coleman, Olivia D. Lara, Christopher J. LaFargue, Karin D. Rodland, Tao Liu, Sherry Y. Wu, Akira Yokoi, Sanghoon Lee, Wen Hu, Lingegowda S. Mangala, Anil K. Sood   +47 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Initial response and 12-month outcomes after commencing dexamethasone or vascular endothelial growth factor inhibitors for retinal vein occlusion in the FRB registry

Scientific Reports
To compare baseline characteristics, initial response and 12-month efficacy and safety outcomes in eyes with branch and central retinal vein occlusion (BRVO and CRVO) treated with dexamethasone implants (DEX) or anti-vascular endothelial growth factor ...
Gonzaga Garay-Aramburu, Adrian Hunt, Carolina Arruabarrena, Hemal Mehta, Alessandro Invernizzi, Pierre-Henry Gabrielle, Tremeur Guillaumie, Benjamin Wolff, Mark C. Gillies, Javier Zarranz-Ventura   +9 more
doaj   +1 more source

Combined therapy versus anti-vascular endothelial growth factor monotherapy for polypoidal choroidal vasculopathy: a Meta-analysis [PDF]

International Journal of Ophthalmology, 2017
AIM: To evaluate the efficacy and safety of anti-vascular endothelial growth factor (VEGF) combined with photodynamic therapy (PDT) versus anti-VEGF monotherapy for polypoidal choroidal vasculopathy (PCV).
Long-Hui Han1, Li-Fei Yuan1, Xu Liang2, Xin Jia1, Ming-Lian Zhang1   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Association of Anti-VEGF Injections with Progression of Geographic Atrophy

, 2016
Age-related macular degeneration (AMD) is one of the leading causes of blindness in developed countries in people over the age of 60 years. One of the forms of advanced AMD is wet AMD.
Sravanthi Vegunta, Sai Bhuvanagiri, Ryan Enslow, Benjamin Cutler, Brian Stagg, Michael Neff   +5 more
core   +1 more source

Gene expression analysis in human breast cancer associated blood vessels [PDF]

, 2012
Angiogenesis is essential for solid tumour growth, whilst the molecular profiles of tumour blood vessels have been reported to be different between cancer types.
John M J Herbert, Jones, DT, Richard Mitter, John M. J. Herbert (132335), Jones D. T., Bicknell, R, Francesca Buffa, Adrian L. Harris (132344), Li Ji-Liang, Li, J-L, Herbert, JMJ, Mitter Richard, Roy Bicknell (54952), Harris A. L., Buffa F., Buffa, Francesca, Mitter, R, Adrian L Harris, Kairbaan Hodivala-Dilke, J Louise Jones, Tanguy Lechertier, Lechertier Tanguy, Tanguy Lechertier (132331), Herbert, JM, Roy Bicknell, Kairbaan Hodivala-Dilke (132348), Herbert John M. J., Lechertier, T, Harris Adrian L., Lechertier T., Francesca Buffa (132341), Hodivala-Dilke Kairbaan, Mitter R., Hodivala-Dilke, K, Jones J. Louise, Ji-Liang Li (132339), Jones, JL, Harris, AL, Buffa, F, Richard Mitter (132333), Bicknell Roy, Li, JL, Dylan T. Jones (132329), Dylan T Jones, Jones Dylan T., Bicknell R., Ji-Liang Li, Herbert J. M. J., Li J. -L., J. Louise Jones (132337), Buffa Francesca, Jones J. L., Hodivala-Dilke K., et al,   +53 more
core   +1 more source