Results 71 to 80 of about 2,389,723 (301)

Digital spatial profiling reveals additive effects of triple therapy on tumor microenvironment: anti-PD-L1, anti-VEGF, and PARP inhibition in mouse models

Cancer Immunology, Immunotherapy
Background Immune checkpoint inhibitors show limited efficacy against immune-desert tumors, including ovarian cancer. We investigated triple therapy combining anti-programmed cell death-ligand 1 (PD-L1) antibody, anti-vascular endothelial growth factor ...
Akihiko Ueda, Ryusuke Murakami, Kentaro Ishida, Kohei Hamada, Jumpei Ogura, Shunsuke Kawahara, Yuka Mise, Yuko Hosoe, Masamichi Sugimoto, Daiko Wakita, Taito Miyamoto, Rin Mizuno, Mana Taki, Koji Yamanoi, Ken Yamaguchi, Junzo Hamanishi, Masaki Mandai   +16 more
doaj   +1 more source

Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics [PDF]

, 2014
Vascular endothelial growth factor-A (VEGF) is produced by most cancer cells as multiple isoforms, which display distinct biological activities. VEGF plays an undisputed role in tumour growth, vascularisation and metastasis; nevertheless the functions of
Reyes-Aldasoro, Constantino C., Steele, A.J., Constantino C Reyes-Aldasoro, Harris Sheila, English William R., English, W. R., Kanthou, Chryso, Diane V Lefley, Reyes-Aldasoro, C.C., Sheila Harris (77307), Reyes-Aldasoro Constantino C., Lefley, D. V., Dos Santos, S. A., Andrew J Steele, English, William R., Dachs, G. U., English, W.R., Steele Andrew J., Sheila Harris, Dachs Gabi U., Greco, Olga, Gillian M. Tozer (167783), Claudia Coralli-Foxon, Kanthou Chryso, Reyes-Aldasoro, C. C., William R English, Steele, Andrew J., Tozer, G. M., Gabi U Dachs, Coralli-Foxon, Claudia, Olga Greco (614634), Harris, S., Olga Greco, Andrew J. Steele (614632), Sofia A. Dos Santos (614635), Dachs, G.U., Dos Santos, S.A., Claudia Coralli-Foxon (614633), Harris, Sheila, Sofia A Dos Santos, Coralli-Foxon Claudia, Greco Olga, Tozer Gillian M., Chryso Kanthou, Gillian M Tozer, Tozer, Gillian M., William R. English (184202), Dos Santos Sofia A., Kanthou, C., Lefley, Diane V., Dos Santos, Sofia A., Chryso Kanthou (22774), Greco, O., Gabi U. Dachs (614630), Steele, A. J., Lefley, D.V., Diane V. Lefley (614631), Dachs, Gabi U., Constantino C. Reyes-Aldasoro (324791), Lefley Diane V., Coralli-Foxon, C., Tozer, G.M.   +61 more
core   +2 more sources

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

VEGF-A: A NOVEL MECHANISTIC LINK BETWEEN CYP2C-DERIVED EET AND NOX4 IN DIABETIC KIDNEY DISEASE

, 2023
Diabetes is associated with decreased epoxyeicosatrienoic acids (EET) bioavailability and increased levels of glomerular vascular endothelial growth factor A (VEGF-A) expression.
Hala Kfoury (14440429), Abdo R. Jurjus (14440434), Assaad A. Eid (11256112), Batoul Dia (14440423), Fuad N. Ziyadeh (11702369), Kawthar Braych (14440416), Rachel Njeim (14440415), Francesco Cappello (55681), Nadim S. Azar (14440420), William S. Azar (14440422), Hilda E. Ghadieh (14440417), Frederic Harb (14440432), Angelo Leone (438313)   +12 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

In vitro analysis of VEGF-mediated endothelial permeability and the potential therapeutic role of Anti-VEGF in severe dengue

Biochemistry and Biophysics Reports
Background: Vascular endothelial growth factor (VEGF) is one of the proteins involved in dengue immunopathogenesis. It is overexpressed in severe dengue and contributes to vascular permeability and plasma leakage.
Sheng Jye Lim, Seng Chiew Gan, Hooi Tin Ong, Yun Fong Ngeow   +3 more
doaj   +1 more source

Tuberculosis pathophysiology and anti-VEGF intervention

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2022
The pathophysiological understanding of tuberculosis is growing, and with this growth comes the possibility of applying established pharmaceuticals in new ways. These new ways interlude with the many mechanisms by which the intracellular pathogen, Mycobacterium tuberculosis, thrives in its human host.
openaire   +3 more sources

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Efficacy and effectiveness of anti-VEGF or steroids monotherapy versus combination treatment for macular edema secondary to retinal vein occlusion: a systematic review and meta-analysis

BMC Ophthalmology, 2022
Background Retinal vein occlusion (RVO) is the main cause of retinal vascular blindness. Laser photocoagulation therapy is the regarded as the standard treatment for branch retinal vein occlusion (BRVO) in the guidelines, but it is not effective for ...
Wuyue Zhang, Yuan Liu, Aimin Sang
doaj   +1 more source