Results 1 to 10 of about 4,644,977 (251)

The ubiquitin-like protein FAT10 in hepatocellular carcinoma cells limits the efficacy of anti-VEGF therapy

Journal of Advanced Research
Introduction: The efficacy of anti-vascular endothelial growth factor (VEGF) therapy is limited. However, the key factors involved in limiting the efficacy of anti-VEGF therapy and the underlying mechanisms remain unclear.
Yumin Qiu, Ben Che, Wenming Zhang, A.V. Zhang, Jin Ge, Dongnian Du, Jiajuan Li, Xiaogang Peng, Jianghua Shao   +8 more
doaj   +4 more sources

Anti-Scg3 Gene Therapy to Treat Choroidal Neovascularization in Mice [PDF]

Biomedicines, 2023
Neovascular age-related macular degeneration (nAMD) with choroidal neovascularization (CNV) is a leading cause of blindness in the elderly in developed countries.
Chengchi Huang, Liyang Ji, Avinash Kaur, Hong Tian, Prabuddha Waduge, Keith A. Webster, Wei Li   +6 more
doaj   +2 more sources

Long-term outcomes of anti-VEGF therapy during cataract surgery in eyes with diabetic macular edema: a five-year retrospective cohort study [PDF]

International Journal of Ophthalmology
AIM: To evaluate the long-term outcomes of anti-vascular endothelial growth factor (VEGF) therapy during cataract surgery in eyes with diabetic macular edema (DME). METHODS: This was a retrospective clinical study.
Xi Chen, Ai-Ai Dai, Tao-Ran Zhang, Xiu-Fen Yang, Ying-Xiang Huang   +4 more
doaj   +2 more sources

Early Switch to Dexamethasone Intravitreal Implant in Patients with Diabetic Macular Edema Poorly Responding to Anti-VEGF Therapy: A Narrative Review [PDF]

Ophthalmology and Therapy
Diabetic macular edema (DME) is a potential complication of diabetic retinopathy (DR) and a leading cause of DR-related impairment of central vision. The pathogenesis of DME is complex and multifactorial.
Riccardo Sacconi, Fabio Scarinci, Maria Oliva Grassi, Giuseppe Covello, Giuseppe Lo Giudice, Elisa De Siena, Vittorio Cacace, Valentina Gallinaro, Roberto Dell’Omo   +8 more
doaj   +2 more sources

Intravitreal anti-vascular endothelial growth factor, laser photocoagulation, or combined therapy for diabetic macular edema: A systematic review and network meta-analysis

Frontiers in Endocrinology, 2023
PurposeTo conduct a network meta-analysis (NMA) comparing the efficacy of anti-vascular endothelial growth factor (VEGF) therapy alone versus laser photocoagulation (LP) therapy alone or anti-VEGF therapy combined with LP therapy for diabetic macular ...
Jiasheng Chen, Jiasheng Chen, Haowei Wang, Haowei Wang, Weiqiang Qiu, Weiqiang Qiu   +5 more
doaj   +1 more source

Evaluation of microaneurysms as predictors of therapeutic response to anti-VEGF therapy in patients with DME

PLoS ONE, 2022
Administration of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the first-line therapy for diabetic macular oedema (DME). However, some patients show no or insufficient response to repeated anti-VEGF injections.
Makoto Hatano, Fumiaki Higashijima, Takuya Yoshimoto, Tadahiko Ogata, Manami Ohta, Yuka Kobayashi, Makiko Wakuta, Ryoji Yanai, Kazuhiro Kimura   +8 more
doaj   +2 more sources

Comparison of antivascular endothelial growth factor treatment for myopia choroidal neovascularisation: a systematic review and meta-analysis of randomised controlled trials

BMJ Open, 2023
Objectives To evaluate the efficacy and safety of anti-vascular endothelial growth factor (anti-VEGF) therapy for myopia choroidal neovascularisation (CNV), and to compare the efficacy of two different anti-VEGF retreatment criteria.Data sources PubMed ...
Chao Zhang, Jie Bai, Liming Dong, Xiao Cheng, Zhihui Song, Guangyao Li   +5 more
doaj   +1 more source

The Impact of VEGF Inhibition on Clinical Outcomes in Patients With Advanced Non-Small Cell Lung Cancer Treated With Immunotherapy: A Retrospective Cohort Study

Frontiers in Oncology, 2021
BackgroundIn recent years, immune checkpoint inhibitors (ICIs) in combination with chemotherapy have increased survival in patients with advanced non-small cell lung cancer (NSCLC).
Keiko Tanimura, Tadaaki Yamada, Ayaka Omura, Shinsuke Shiotsu, Nobutaka Kataoka, Takayuki Takeda, Ryusuke Taniguchi, Takahiro Yamada, Mayumi Takeuchi, Yusuke Chihara, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Koichi Takayama   +14 more
doaj   +1 more source

Efficacy and safety profile of intravitreal dexamethasone implant versus antivascular endothelial growth factor treatment in diabetic macular edema: a systematic review and meta-analysis

Scientific Reports, 2023
To better understand the efficacy of intravitreal dexamethasone implant (Ozurdex) versus antivascular endothelial growth factor (anti-VEGF) treatment in patients with diabetic macular edema (DME). A systematic review and meta-analysis. The study included
Sheng-Chu Chi, Yi-No Kang, Yi-Ming Huang
doaj   +1 more source

Combined therapy versus anti-vascular endothelial growth factor monotherapy for polypoidal choroidal vasculopathy: a Meta-analysis [PDF]

International Journal of Ophthalmology, 2017
AIM: To evaluate the efficacy and safety of anti-vascular endothelial growth factor (VEGF) combined with photodynamic therapy (PDT) versus anti-VEGF monotherapy for polypoidal choroidal vasculopathy (PCV).
Long-Hui Han1, Li-Fei Yuan1, Xu Liang2, Xin Jia1, Ming-Lian Zhang1   +4 more
doaj   +1 more source