Results 181 to 190 of about 69,808 (218)
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Recent updates for designing CCR5 antagonists as anti-retroviral agents
European Journal of Medicinal Chemistry, 2018The healthcare system faces various challenges in human immunodeficiency virus (HIV) therapy due to resistance to Anti-Retroviral Therapy (ART) as a consequence of the evolutionary process. Despite the success of antiretroviral drugs like Zidovudine, Zalcitabine, Raltegravir WHO ranks HIV as one of the deadliest diseases with a mortality of one million
Harshil R, Shah, Jignasa Ketan, Savjani
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Low dose total body irradiation: a potent anti-retroviral agent in vivo
International Journal of Radiation Oncology*Biology*Physics, 1989Immunosuppression characterizes many human diseases including leukemia and AIDS. Friend virus (FV)-induced murine leukemia is a useful model for studying both malignancy and immunosuppression. In a previous series of experiments, we have demonstrated that untreated FV-infected mice died within 40 days post-infection, whereas infected mice given 150 cGy
R N, Shen +5 more
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Chemosphere, 2022
This work aims to develop an electrochemical sensor for the reusable and selective detection of trace levels of indinavir (IDV) as an anti-retroviral drug by using zinc oxide nano-rods/molybdenum disulfide nanosheets on a screen-printed electrode (ZnO NRs/MoS2 NSs/SPE). Quantitative IDV detection was achieved using differential pulse voltammetry (DPV).
Mohammad Mehmandoust +2 more
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This work aims to develop an electrochemical sensor for the reusable and selective detection of trace levels of indinavir (IDV) as an anti-retroviral drug by using zinc oxide nano-rods/molybdenum disulfide nanosheets on a screen-printed electrode (ZnO NRs/MoS2 NSs/SPE). Quantitative IDV detection was achieved using differential pulse voltammetry (DPV).
Mohammad Mehmandoust +2 more
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Journal of Medicinal Chemistry, 1998
Agents that target the two highly conserved Zn fingers of the human immunodeficiency virus (HIV) nucleocapsid p7 (NCp7) protein are under development as antivirals. These agents covalently modify Zn-coordinating cysteine thiolates of the fingers, causing Zn ejection, loss of native protein structure and nucleic acid binding capacity, and disruption of ...
M, Huang +6 more
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Agents that target the two highly conserved Zn fingers of the human immunodeficiency virus (HIV) nucleocapsid p7 (NCp7) protein are under development as antivirals. These agents covalently modify Zn-coordinating cysteine thiolates of the fingers, causing Zn ejection, loss of native protein structure and nucleic acid binding capacity, and disruption of ...
M, Huang +6 more
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[Evaluation of resistance to anti-retroviral agents. Publication of clinical trials].
Enfermedades infecciosas y microbiologia clinica, 2000Information on patterns of resistance to and cross-resistance between antiretroviral agents is increasingly available and may be important for decisions on how to combine drugs to achieve an optimum antiviral effect in future therapeutic strategies. The increasing number of heavily pre-treated patients have changed the approach to assist therapeutic ...
D, Dalmau, A, Ochoa de Echagüen
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[Update on drug allergies induced by antibiotics and anti-retroviral agents].
Bulletin de l'Academie nationale de medecine, 2000Allergic reactions to antibiotics have raised considerable concerns, and are still underevaluated. It is a daily problem for general practitioners and allergologists. Their clinical manifestations are numerous, ranging from mild maculo-papular eruptions to sometimes deadly anaphylactic shocks or epidermal necrolisis.
P, Demoly +3 more
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Enfermedades infecciosas y microbiologia clinica, 2002
To determine the prevalence of the in vitro resistance rate of cytomegalovirus (CMV) to gancyclovir (GCV) and foscarnet (FOS) among patients with AIDS and chorioretinitis. Furthermore, in vitro sensitivity results were compared with the clinical response to therapy.Thirty-six patients with the diagnosis of CMV retinitis and AIDS were included in the ...
M A, Cañizares +6 more
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To determine the prevalence of the in vitro resistance rate of cytomegalovirus (CMV) to gancyclovir (GCV) and foscarnet (FOS) among patients with AIDS and chorioretinitis. Furthermore, in vitro sensitivity results were compared with the clinical response to therapy.Thirty-six patients with the diagnosis of CMV retinitis and AIDS were included in the ...
M A, Cañizares +6 more
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Journal of Computational Biophysics and Chemistry
The development of effective antiretroviral inhibitors (HIV-1 Reverse Transcriptase) and glucosamine-6-phosphate (GlcN6P) agents represent a significant challenge for combating viral infections and related diseases. In this study, we employed a multidisciplinary approach to design and evaluate a series of novel triazole analogs as potential candidates
Rahul Ghosh, Swastika Ganguly
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The development of effective antiretroviral inhibitors (HIV-1 Reverse Transcriptase) and glucosamine-6-phosphate (GlcN6P) agents represent a significant challenge for combating viral infections and related diseases. In this study, we employed a multidisciplinary approach to design and evaluate a series of novel triazole analogs as potential candidates
Rahul Ghosh, Swastika Ganguly
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In vitro pharmacodynamic modeling of anti-retroviral agents and interferon
Antiviral Research, 1991J.A. Bilello, M.N. Dudley, G.L. Drusano
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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