Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine [PDF]
Pharmacol Res Perspect, 2015 Mexiletine is a sodium channel blocker, primarily used in the treatment of ventricular arrhythmias. Moreover, recent studies have demonstrated its therapeutic value to treat myotonic syndromes and to relieve neuropathic pain.
Roberta Gualdani +6 more
semanticscholar +2 more sources
The Resurfacing of Bepridil Hydrochloride on the World Stage as an Antiarrhythmic Drug for Atrial Fibrillation [PDF]
Journal of Arrhythmia, 2009 Bepridil hydrochloride is a multiple ion channel blocker with relatively strong suppressive effects for various K+ channels. Recent clinical studies mainly done in Japan have revealed the eficacy of the agent for the management of atrial fibrillation (AF)
Barcelona Activa, S.A. +2 more
core +6 more sources
Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agent [PDF]
Acta Pharmacol Sin, 2011 Aim:To examine the electrophysiological effects of sophocarpine on action potentials (AP) and ionic currents of cardiac myocytes and to compare some of these effects with those of amiodarone.Methods:Langendorff perfusion set-up was used in isolated ...
Zhi-fang Yang +6 more
semanticscholar +2 more sources
Терапевтический архив, 2015 Aim. To evaluate the efficacy and safety of refralon (niferidil), a new class III antiarrhythmic agent whose activity is related to the block of delayed rectifying potassium current and to the prolongation of atrial and ventricular action potential and ...
E. Maykov +6 more
semanticscholar +3 more sources
Practice Variation in Establishing the Adequacy of Beta-Blockers as an Antiarrhythmic Agent in School-Aged Children and Adolescents [PDF]
CJC Open, 2020 Background: Beta-blockers (BBs) are commonly prescribed to manage arrhythmias in children and adolescents without any standardised approach to establish BB adequacy. We invited all Canadian pediatric cardiologists to participate in an anonymous survey to
Hilal Al Riyami, MD +3 more
doaj +2 more sources
Intra‐Operative Lidocaine Management in the Setting of Ventricular Tachycardia Storm: A Case Report [PDF]
Clinical Case ReportsEffective management of VT storm during catheter ablation involves discontinuation of antiarrhythmic agents to facilitate VT induction for mapping of the critical isthmus.
Cassandra Williams +4 more
doaj +2 more sources
Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs [PDF]
Research Results in Pharmacology, 2016 It was shown that the indole derivate SS-68 (50 and 250 μg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is associated with the neurotropic influence of this ...
Bogus, S. K. +4 more
core +6 more sources
Reappraising Use of Flecainide for Atrial Fibrillation and Ventricular Arrhythmias in Structural Heart Disease Patients [PDF]
MedicinaBackground: Flecainide, a class Ic antiarrhythmic agent, has long been contraindicated in structural heart disease (SHD) due to findings of the Cardiac Arrhythmia Suppression Trial (CAST).
Dimitrios Tsiachris +10 more
doaj +2 more sources
Disopyramide Therapy in Cats with Obstructive Hypertrophic Cardiomyopathy Non-Responsive to Carvedilol [PDF]
Veterinary SciencesHypertrophic cardiomyopathy (HCM) is the most common cardiomyopathy in cats and is classified as obstructive (HOCM) or non-obstructive based on anatomical differences in the left ventricular outflow tract (LVOT).
Shuji Satomi +6 more
doaj +2 more sources
Antiarrhythmic properties of N-Deacetyllappaconitine Hydrochloride
Фармакокинетика и Фармакодинамика, 2022 The aim of the investigation was the research of the N-deacetyllappaconitine hydrochloride antiarrhythmic properties. It was found that the studied substance was effective on the cardiac arrhythmias model caused by aconitine hydrochloride, but does not ...
S. A. Kryzhanovskii +4 more
doaj +1 more source