Results 11 to 20 of about 3,249,675 (219)

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine.

Angewandte Chemie, 2021
Na v 1.5, the primary voltage-gated Na + (Na v ) channel in heart, is a major target for class I antiarrhythmic agents. Here we present the cryo-EM structure of full-length human Na v 1.5 bound to quinidine, a class Ia antiarrhythmic drug, at 3.3 Å ...
Zhangqiang Li, Xueqin Jin, Tong Wu, Gaoxingyu Huang, Kun Wu, J. Lei, Xiaojing Pan, N. Yan   +7 more
semanticscholar   +1 more source

Systematic review of the safety and efficacy of antazoline in the treatment of atrial fibrillation. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: In the emergency department, patients with recent-onset atrial fibrillation are typically managed with intravenous antiarrhythmic agents. However, the currently used agents have a low efficacy and safety profile.
Raghad Aldulaymi, Ahmad Z. Al Meslamani
doaj  

Identification of potentially effective antiarrhythmic drugs to individualize premature ventricular contraction therapy in patients without structural cardiac changes

Российский кардиологический журнал, 2020
Aim. To individualize premature ventricular contraction (PVC) therapy in patients without structural cardiac changes by identifying potentially effective antiarrhythmic agents.Material and methods.
A. I. Olesin, I. V. Konstantinova, Yu. S. Zueva, A. V. Koziy   +3 more
doaj   +1 more source

Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair [PDF]

, 2015
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of ...
Olson, Eric N., van Rooij, Eva
core   +1 more source

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Frontiers in Tropical Diseases, 2023
The repurposing of approved drugs is an appealing method to fast-track the development of novel therapies for neglected diseases. Amiodarone and dronedarone, two approved antiarrhythmic agents, have been reported to have potential for the management of ...
Amanda F. Francisco, Gong Chen, Wen Wang, Melissa L. Sykes, Fanny Escudié, Ivan Scandale, Francisco Olmo, David M. Shackleford, Bilal Zulfiqar, Jadel M. Kratz, Thao Pham, Jessica Saunders, Meiyu Hu, Vicky M. Avery, Susan A. Charman, John M. Kelly, Eric Chatelain   +16 more
doaj   +1 more source

Micro-RNA family that modulates fibrosis and uses thereof [PDF]

, 2017
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response
Olson, Eric N., van Rooij, Eva
core   +1 more source

Convergent Synthesis of Dronedarone, an Antiarrhythmic Agent.

Chemical and pharmaceutical bulletin, 2016
We have developed a convergent synthesis of dronedarone, an antiarrhythmic agent. The key steps of the process are the construction of a benzofuran skeleton by iodocyclization and the carbonylative Suzuki-Miyaura cross-coupling for biaryl ketone ...
Takashi Okitsu, Mizuki Ogasahara, A. Wada   +2 more
semanticscholar   +1 more source

Initiation and outcomes with Class Ic antiarrhythmic drug therapy

Indian Pacing and Electrophysiology Journal, 2018
Background: Expert opinion recommends performing exercise testing with initiation of Class Ic antiarrhythmic medication. Objective: To evaluate the rate and reason for discontinuation of Ic agent within the first year of follow up, with particular ...
Xu Gao, Avirup Guha, Benjamin Buck, Dilesh Patel, Melissa J. Snider, Michael Boyd, Muhammad Afzal, Auroa Badin, Hemant Godara, Zhenguo Liu, Jaret Tyler, Raul Weiss, Steven Kalbfleisch, John Hummel, Ralph Augostini, Mahmoud Houmsse, Emile G. Daoud   +16 more
doaj   +1 more source

Arrhythmia induction using isoproterenol or epinephrine during electrophysiology study for supraventricular tachycardia [PDF]

, 2018
Background Electrophysiology study (EPS) is an important part of the diagnosis and workup for supraventricular tachycardia (SVT). Provocative medications are used to induce arrhythmias, when they are not inducible at baseline. The most common medication
Padanilam, Benzy J., Patel, Jyoti Kandlikar, Patel, Parin J., Prystowsky, Eric N., Segar, Rachel   +4 more
core   +1 more source

Inhibitory effects of class I antiarrhythmic agents on Na+ and Ca2+ currents of human iPS cell-derived cardiomyocytes

Regenerative Therapy, 2019
Introduction: Human induced pluripotent stem cells (hiPSCs) harboring cardiac myosin heavy chain 6 promoter can differentiate into functional cardiomyocytes called “iCell cardiomyocytes” under blasticidin treatment condition.
Sayaka Yonemizu, Keiichiro Masuda, Yasutaka Kurata, Tomomi Notsu, Yuhei Higashi, Kenta Fukumura, Peili Li, Haruaki Ninomiya, Junichiro Miake, Motokazu Tsuneto, Yasuaki Shirayoshi, Ichiro Hisatome   +11 more
doaj   +1 more source