Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes. [PDF]
PLoS ONE, 2017 BACKGROUND:Ibutilide, a class III antiarrhythmic agent has been shown to be cardioprotective in treating atrial fibrillation, promoting cardioconversion and recently this agent has been shown to protect against ER stress induced apoptosis in ...
Yu Wang +6 more
doaj +1 more source
Endothelin and the ischaemic heart [PDF]
, 2005 Soon after its identification as a powerful vasoconstrictor peptide, endothelin (ET-1) was implicated as a detrimental agent involved in determining the outcome of myocardial ischaemia and reperfusion.
Kane, K.A., McCabe, C., Wainwright, C.L.
core +1 more source
Tratamiento antiarrítmico actual de la fibrilación auricular no valvular en España: datos del Registro FANTASIIA [PDF]
, 2015 [Abstract] Introduction and objectives. Recently, there have been many developments in the management of nonvalvular atrial fibrillation, antiarrhythmic and anticoagulant therapy, and nonpharmacological treatment, but these developments are not applied ...
Anguita Sanchez, Manuel +10 more
core +2 more sources
Phytochemical Compounds and Protection from Cardiovascular Diseasesa. A State of the Art [PDF]
, 2015 Cardiovascular diseases represent a worldwide relevant socioeconomical problem. Cardiovascular disease prevention relies also on lifestyle changes, including dietary habits.
PAGLIARO, BENIAMINO ROSARIO +3 more
core +4 more sources
Dofetilide induced torsade de pointes: Mechanism, risk factors and management strategies
Indian Heart Journal, 2014 Dofetilide is an effective antiarrhythmic agent for conversion of atrial fibrillation and atrial flutter as well as maintenance of sinus rhythm in appropriately selected patients.
Abhishek Jaiswal, Seth Goldbarg
doaj +1 more source
Mexiletine-like cellular electrophysiological effects of GS967 in canine ventricular myocardium
Scientific Reports, 2021 Enhancement of the late Na+ current (INaL) increases arrhythmia propensity in the heart, while suppression of the current is antiarrhythmic. GS967 is an agent considered as a selective blocker of INaL.
Tamás Hézső +20 more
doaj +1 more source
Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation [PDF]
, 2012 Coronary artery disease and heart failure carry concurrent risk for atrial fibrillation and life-threatening ventricular arrhythmias. We review evidence indicating that at therapeutic concentrations, ranolazine has potential for dual suppression of these
Belardinelli, Luiz +3 more
core +1 more source
Identification of New KCNT1‐Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling
Annals of Neurology, EarlyView.Objective Hyperactive KCNT1 potassium channels, caused by gain‐of‐function mutations, are associated with a range of epilepsy disorders. Patients typically experience drug‐resistant seizures and, in cases with infantile onset, developmental regression can follow.
Michael G. Ricos +9 more
wiley +1 more source
Current Directions in Biomedical Engineering, 2015 Vernakalant is a new antiarrhythmic agent for the treatment of atrial fibrillation. While it has proven to be effective in a large share of patients in clinical studies, its underlying mode of action is not fully understood.
Loewe Axel +4 more
doaj +1 more source
Therapeutic drug monitoring education: The current state
British Journal of Clinical Pharmacology, EarlyView.Aims To evaluate available information on therapeutic drug monitoring (TDM) education programmes and their implementation across different countries. Methods The study was performed in two phases. First, a scoping review of scientific literature on available education programmes was performed.
Guenka Petrova +10 more
wiley +1 more source