Results 41 to 50 of about 19,342 (221)

Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions

Current Directions in Biomedical Engineering, 2015
Vernakalant is a new antiarrhythmic agent for the treatment of atrial fibrillation. While it has proven to be effective in a large share of patients in clinical studies, its underlying mode of action is not fully understood.
Loewe Axel, Xu Yan, Scholz Eberhard P., Dössel Olaf, Seemann Gunnar   +4 more
doaj   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review

Frontiers in Cardiovascular Medicine, 2022
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new type of oral hypoglycaemic agent with good cardiovascular protective effects. There are several lines of clinical evidence suggest that SGLT2i can significantly reduce the risks of heart ...
Jinchun Wu, Yanmin Liu, Xiaojuan Wei, Xiaofei Zhang, Yi Ye, Wei Li, Xiaoling Su   +6 more
doaj   +1 more source

Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation [PDF]

, 2012
Coronary artery disease and heart failure carry concurrent risk for atrial fibrillation and life-threatening ventricular arrhythmias. We review evidence indicating that at therapeutic concentrations, ranolazine has potential for dual suppression of these
Belardinelli, Luiz, Kumar, Kapil, Nieminen, Tuomo, Verrier, Richard L.   +3 more
core   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Electrical storm after cardiac resynchronization therapy in a patient with nonischemic cardiomyopathy: Signal‐averaged vector‐projected 187‐channel electrocardiogram‐based risk stratification for lethal arrhythmia

Journal of Arrhythmia, 2013
We describe treatment of atrial flutter and electrical storm presenting as incessant ventricular tachycardia (VT) after implantation of a cardiac resynchronization therapy defibrillator (CRT‐D) in a patient with dilated cardiomyopathy.
Toshiko Nakai, Hiroaki Mano, Yukitoshi Ikeya, Kazumasa Sonoda, Sonoko Ashino, Yasuo Okumura, Kimie Ohkubo, Satoshi Kunimoto, Yuji Kasamaki, Ichiro Watanabe, Atsushi Hirayama, Kenji Nakai   +11 more
doaj   +1 more source

Arctigenin, a Potential Anti-Arrhythmic Agent, Inhibits Aconitine-Induced Arrhythmia by Regulating Multi-Ion Channels

Cellular Physiology and Biochemistry, 2013
Background/Aims: Arctigenin possesses biological activities, but its underlying mechanisms at the cellular and ion channel levels are not completely understood.
Zhenying Zhao, Yongqiang Yin, Hong Wu, Min Jiang, Jianshi Lou, Gang Bai, Guo‘an Luo   +6 more
doaj   +1 more source

Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium [PDF]

PeerJ, 2017
Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity.
Jesús Hernandez-Cascales
doaj   +2 more sources

Electrical Storms in Brugada Syndrome: Review of Pharmacologic and Ablative Therapeutic Options [PDF]

, 2005
Electrical storm occurring in a patient with the Brugada syndrome is an exceptional but malignant and potentially lethal event. Efficient therapeutic solutions should be known and urgently applied because of the inability of usual antiarrhythmic means in
Haïssaguerre, M, Hocini, M, Maury, P
core   +2 more sources

Association of Abatacept With Lower Mortality Risk Compared to Rituximab in Rheumatoid Arthritis–Associated Interstitial Lung Disease: An Emulated Target Trial

Arthritis &Rheumatology, EarlyView.
Objective The optimal treatment strategy for rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) remains uncertain, and direct comparative data between biologics are limited. This study aimed to evaluate the effectiveness and safety of abatacept compared with rituximab in patients with RA‐ILD.
Po‐Cheng Shih, Shiow‐Ing Wang, Qing‐Wen Wang, James Cheng Chung Wei   +3 more
wiley   +1 more source