Results 51 to 60 of about 19,342 (221)

The Role of Ranolazine in the Treatment of Ventricular Tachycardia and Atrial Fibrillation: A Narrative Review of the Clinical Evidence

Biomedicines
Cardiac arrhythmias are among the leading causes of morbidity and mortality worldwide. While antiarrhythmic drugs traditionally represent the first-line management strategy, their use is often limited by profound proarrhythmic effects.
Kyosuke Murai, Amir Vasigh, Tamás Alexy, Kálmán Tóth, László Czopf   +4 more
doaj   +1 more source

Pharmacological Treatment for Atrial Fibrillation

Journal of Arrhythmia, 2005
Pharmacological treatment for atrial fibrillation has a variety of purposes, such as pharmacological defibrillation, maintenance of sinus rhythm, heart rate control to prevent congestive heart failure and prevention of both cerebral infarction and atrial
Kaoru Sugi, MD PhD, Mahito Noro, MD PhD, Takao Sakata, MD PhD, Naoki Tezuka, MD, Takeshi Nakae, MD, Kenta Kumagai, MD, Tsuyoshi Sakai, MD PhD, Ayaka Numata, MD PhD, Hidetoshi Itakura, MD, Akiyoshi Moriyama, MD, Shingo Kujime, MD   +10 more
doaj   +1 more source

Non-valvular atrial fibrillation and stroke : implications for management [PDF]

, 1995
Nonvalvular Atrial Fibrillation is more prevalent with increasing age. It is associated with a six-fold excess risk of stroke; and a cumulative lifetime stroke risk of 35%. 15% of ischaemic strokes are directly attributable to it.
Tilney, Myra Kay
core  

Micro-RNAS that control myosin expression and myofiber identity [PDF]

, 2015
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber
Olson, Eric N., van Rooij, Eva
core   +1 more source

Comparative effectiveness and safety of oral anticoagulants in patients with atrial fibrillation using antiarrhythmic drugs: An international cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Our international cohort study assessed the comparative effectiveness and safety of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) among patients with non‐valvular atrial fibrillation (NVAF) using antiarrhythmic drugs. Methods Using the United Kingdom's (UK's) Clinical Practice Research Datalink Aurum and Québec claims data, we
Fabian Maximilian Meinert, Jenny Dimakos, Ying Cui, Kristian B. Filion, Christel Renoux, Antonios Douros   +5 more
wiley   +1 more source

Clinical study of Russian class III antiarrhythmic agent, nibentan, in supraventricular arrhythmia management

Кардиоваскулярная терапия и профилактика, 2005
Aim. To study clinical efficacy of a new, class III, antiarrhythmic agent, nibentan, in various supraventricular (SV) cardiac arrythmias. Material and methods.
V. G. Valiev, A. E. Radzevich, V. A. Gorshkov, E. M. Zeltyn, A. B. Besprozvanny, E. N. Ostroumov   +5 more
doaj  

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations. [PDF]

, 2019
Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome.
Chen, I-Shan, Furutani, Kazuharu, Handa, Kenichiro, Kurachi, Yoshihisa, Sack, Jon T, Tsumoto, Kunichika, Yamakawa, Yuko   +6 more
core   +1 more source

Drugs and life-threatening ventricular arrhythmia risk: results from the DARE study cohort. [PDF]

, 2017
OBJECTIVES: To establish a unique sample of proarrhythmia cases, determine the characteristics of cases and estimate the contribution of individual drugs to the incidence of proarrhythmia within these cases.
Behr, ER, Camm, AJ, Coughtrie, AL, Layton, D, Marshall, V, Shakir, SAW   +5 more
core   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Effects of a Novel Cyclohexane Dicarboximide Derivative, ST-6, on Reperfusion-Induced Arrhythmia in Rats

Journal of Pharmacological Sciences, 2005
The present study was designed to determine whether a novel cyclohexane dicarboximide derivative, ST-6, 2-[4-[4-(chlorophenyl)-4-hydroxy-1-piperidinyl]butyl]hexahydro-1H-isoindol-1,3(2H)-dione, prevents reperfusion-induced ventricular arrhythmias ...
Hiroshi Kajiwara, Itaru Ohoi, Kouichi Tanonaka, Satoshi Takeo   +3 more
doaj   +1 more source