Results 71 to 80 of about 3,249,675 (219)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Drug-induced Brugada syndrome

Journal of Arrhythmia, 2013
Brugada syndrome (BrS) is an inherited cardiac disorder that is associated with an electrocardiogram pattern of ST segment elevation on right precordial leads and a high incidence of sudden death.
Yoshino Minoura, Youichi Kobayashi, Charles Antzelevitch   +2 more
doaj   +1 more source

A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG. [PDF]

PLoS ONE, 2016
Class IC antiarrhythmic agents may induce acquired forms of Brugada Syndrome. We have identified a novel mutation in SCN5A, the gene that encodes the α-subunit of the human cardiac sodium channel (hNav1.5), in a patient who exhibited Brugada- type ECG ...
Isik Turker, Takeru Makiyama, Matteo Vatta, Hideki Itoh, Takeshi Ueyama, Akihiko Shimizu, Tomohiko Ai, Minoru Horie   +7 more
doaj   +1 more source

Isorhythmic atrioventricular dissociation during anaesthesia in a cat

Veterinary Record Case Reports, EarlyView.
Abstract A 10‐year‐old, male, neutered domestic shorthair cat with suspected hypertrophic cardiomyopathy was referred for cystotomy to remove uroliths present in its urinary bladder. Fifteen minutes after induction of general anaesthesia, atrioventricular dissociation was noted on the electrocardiogram with similar atrial and ventricular firing rates ...
Gemma Padrosa Sala, Cristian Cabellos Clemente, Paul Wotton, Frane Ivasovic   +3 more
wiley   +1 more source

Treatment of Electrical Storm with Amiodarone in Brugada Syndrome- an Unexpected Protective Effect [PDF]

, 2013
We are reporting on a 53 year old man with proven Brugada syndrome and ICD implantation for resuscitation in context of polymorphic VT. After recurrent arrhythmia he was treated with Amiodarone.
Lambiase, PD, Novak, J
core   +1 more source

Prehospital Atrial Fibrillation: Clinical and Economic Aspects

Общая реаниматология, 2012
Objective: to retrospectively study the results of emergency medical care for patients with uncomplicated attacks of atrial fibrillation and to provide a clinical and economic assessment of their prehospital management tactics. Material and methods.
V. T. Dolgikh, V. G. Epifanov
doaj   +1 more source

Comparative cardiovascular risk of sulfonylureas with low‐ and high‐affinities for cardiac mitochondrial adenosine triphosphate‐sensitive potassium channels versus dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes: A cohort study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To individually evaluate the cardiovascular safety of low‐ and high‐affinity cardiac mitochondrial ATP‐sensitive potassium (mitoKATP) channel sulfonylureas by comparing each to dipeptidyl peptidase‐4 inhibitors (DPP‐4i), a generally cardiovascular‐neutral comparator, given prior evidence suggesting greater cardiovascular risk with high ...
Mei‐Hsiu Chen, Liang‐Yu Lin, Tung‐Ying Hung, Tzu‐Chieh Lin, Chia‐Yu Li, Tzu‐Han Lin, Yi‐Hsuan Chen, Jun‐Ting Liou, Meng‐Ting Wang   +8 more
wiley   +1 more source

On mechanism of antiarrhythmic action of some dimethylphenylacetamide derivatives [PDF]

, 2018
The study aim was to identify essential elements of the antiarrhythmic action mechanism of tertiary and quaternary derivatives of Dimethylphenylacetamide.
Blinova, E. V., Kurganov, N. A., Lebedev, A. B., Mohamed Hameed Salem Yahya, Semeleva, E. V.   +4 more
core   +2 more sources

Metabolic bariatric surgery is associated with reduced adverse hepatic and extrahepatic outcomes, and lower all‐cause mortality, in patients with steatotic liver disease

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aim Metabolic bariatric surgery (MBS) improves histological endpoints in steatotic liver disease (SLD), but data on longer‐term clinical outcomes in this population are scarce. Here, we assessed the impact of MBS on hepatic and extrahepatic morbidity and mortality in individuals with SLD.
Weronika Stupalkowska, Alexander Henney, Eric G. Sheu, Uazman Alam, Daniel J. Cuthbertson   +4 more
wiley   +1 more source

Cardiac Potassium Channels: Physiological Insights for Targeted Therapy. [PDF]

, 2017
The development of novel drugs specifically directed at the ion channels underlying particular features of cardiac action potential (AP) initiation, recovery, and refractoriness would contribute to an optimized approach to antiarrhythmic therapy that ...
A. John Camm, Christopher L.-H. Huang, Feng J, Hansen RS, Kamalan Jeevaratnam, Karan R. Chadda, Lepran I, Milnes JT, Nichols CG, Rampe D, Rampe D, Shieh CC, Wang Z, Zhao X, Zhou J   +14 more
core   +1 more source