Results 171 to 180 of about 42,053 (270)

Kidney Effectiveness and Safety of Adding Spironolactone in Patients With Type 2 Diabetes Receiving Renin–Angiotensin System Inhibitors Therapy

open access: yesClinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT We evaluated the renal outcomes and safety of spironolactone added to renin–angiotensin system inhibitors (RASis) among patients with type 2 diabetes (T2D), given its uncertain role alongside RASis, the cornerstone of T2D with renal disease management.
Wei‐Ren Lin   +7 more
wiley   +1 more source

QT Myopia and Cardiac Safety: Expanding the Aperture of Arrhythmia Assessment in Early Phase Drug Development

open access: yesClinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Regulatory agencies such as the Food and Drug Administration (FDA), European Medicines Agency (EMA), Health Canada, and the Japanese Pharmaceutical and Medical Device Agency (PMDA) provide scientific and public health guidance with cardiac safety being paramount in drug development of new investigational products (IP).
Robert M. Lester   +2 more
wiley   +1 more source

Bachmann's Bundle‐Related Atrial Tachycardias Following Catheter Ablation of Persistent Atrial Fibrillation

open access: yesJournal of Cardiovascular Electrophysiology, Volume 37, Issue 3, Page 561-571, March 2026.
ABSTRACT Background Atrial tachycardias (AT) after radiofrequency ablation (RFA) of atrial fibrillation (AF) may utilize Bachmann's bundle (BB). Due to their epicardial location, these ATs remain poorly understood. Objective To describe the electrophysiologic and anatomic basis of BB‐related ATs.
Nate Christian‐Miller   +10 more
wiley   +1 more source

Very High‐Power Short‐Duration Ablation for Premature Ventricular Complexes From Sites With Suboptimal Catheter Stability

open access: yesJournal of Cardiovascular Electrophysiology, Volume 37, Issue 3, Page 652-654, March 2026.
ABSTRACT Introduction While very high‐power short‐duration (vHPSD) ablation has been shown to be safe and effective for ablation of atrial fibrillation, the utility of vHPSD ablation for targeting premature ventricular complexes (PVCs) remains unclear.
Heather Wheat   +5 more
wiley   +1 more source

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