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Hopes and disappointments with antiarrhythmic drugs [PDF]

open access: yesInternational Journal of Cardiology, 2017
Ventricular arrhythmias such as sustained ventricular tachycardia and ventricular fibrillation account for two thirds of sudden cardiac deaths. Most ventricular tachyarrhythmias have well understood mechanisms such that it is theoretically possible to ...

exaly   +2 more sources

Investigational antiarrhythmic agents: promising drugs in early clinical development

open access: yesExpert Opinion on Investigational Drugs, 2017
Introduction: Although there have been important technological advances for the treatment of cardiac arrhythmias (e.g., catheter ablation technology), antiarrhythmic drugs (AADs) remain the cornerstone therapy for the majority of patients with ...
Jordi Heijman, Dobromir Dobrev
exaly   +2 more sources

Antiarrhythmic drugs

Current Treatment Options in Cardiovascular Medicine, 2004
Both supraventricular and ventricular arrhythmias are associated with increased mortality and morbidity. Numerous antiarrhythmics have been developed in an attempt to decrease the frequency of these arrhythmias, hoping to improve survival and improve quality of life.
Steven N., Singh   +2 more
openaire   +2 more sources

Antiarrhythmic drugs in pregnancy

Expert Review of Cardiovascular Therapy, 2015
The risk of arrhythmia development or recurrence is increased during pregnancy. For those arrhythmias that are unresponsive to conservative therapy, such as vagal maneuvers or life style interventions, or that present a higher risk to the mother or fetus, medical therapy may be necessary.
Jennifer M, Wright   +2 more
openaire   +2 more sources

Antiarrhythmic drugs and epilepsy

Pharmacological Reports, 2014
For a long time it has been suspected that epilepsy and cardiac arrhythmia may have common molecular background. Furthermore, seizures can affect function of the central autonomic control centers leading to short- and long-term alterations of cardiac rhythm. Sudden unexpected death in epilepsy (SUDEP) has most likely a cardiac mechanism.
Kinga K. Borowicz, Monika Banach
openaire   +2 more sources

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