Results 121 to 130 of about 41,794 (337)
Present and future of antiarrhythmic therapy for atrial fibrillation: A review
Consilium MedicumDespite the emergence and active development of interventional methods for the treatment of arrhythmias, to date, the use of antiarrhythmic drugs to recover and maintain sinus rhythm is the most significant and in demand in patients with paroxysmal and ...
Aida I. Tarzimanova
doaj +1 more source
Rabbit models of heart disease. [PDF]
, 2008 Human heart disease is a major cause of death and disability. A variety of animal models of cardiac disease have been developed to better understand the etiology, cellular and molecular mechanisms of cardiac dysfunction and novel therapeutic strategies ...
Bers, Donald M, Pogwizd, Steven M
core
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev +7 more
wiley +1 more source
Electrophysiological Effects of Extracellular Vesicles Secreted by Cardiosphere-Derived Cells: Unraveling the Antiarrhythmic Properties of Cell Therapies [PDF]
, 2020 L Gómez-Cid +8 more
openalex +1 more source
Cost effectiveness of the implantable cardioverter defibrillator: a preliminary analysis [PDF]
, 1992 Background-An implantable cardioverter defibrillator (ICD) maybe effective in reducing the risk of sudden cardiac death. The high cost of ICD treatment, however, compared with alternatives raises the question of whether this new technology is an ...
Buxton, MJ, O'Brien, BJ, Rusby, RA
core
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices
The Journal of Physiology, EarlyView.Abstract figure legend ent‐Vert selectively inhibits RyR2‐mediated sarcoplasmic reticulum (SR) Ca2+ leak and prevents triggered activity in human cardiac slices. A, in human ventricular slices exposed to β‐adrenergic stimulation with Iso and RyR2 sensitization with caffeine, RyR2 channels become hyperactive, leading to Ca2+ sarcoplasmic leak and ...
Micah K. Madrid +6 more
wiley +1 more source
Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö +8 more
wiley +1 more source
Antiarrhythmic therapy: quinidine gluconate vs procainamide. [PDF]
, 1980 M. Kletzkin
openalex +1 more source