Results 191 to 200 of about 2,377,916 (241)
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Is There a Future for Antiarrhythmic Drug Therapy?
Drugs, 1998Drug therapy has traditionally been the mainstay of treatment for both ventricular and supraventricular arrhythmias. However, increasing knowledge about the potentially significant adverse effects of these medications, together with the emergence of new, nonpharmacological approaches to the treatment of arrhythmias, has led some to question the future ...
P G, Guerra +5 more
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Importance of metabolites in antiarrhythmic therapy
The American Journal of Cardiology, 1983The presence of metabolites with pharmacologic activity can produce unanticipated drug efficacy or toxicity. This is particularly true during treatment with drugs that have narrow therapeutic-toxic ratios, such as the antiarrhythmic agents. The presence of active metabolites can often be inferred from variability in the relation between pharmacologic ...
R L, Woosley, D M, Roden
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Advances in Antiarrhythmic Therapy
Veterinary Clinics of North America: Small Animal Practice, 1998The therapy of cardiac arrhythmias in small animals can be confusing and challenging. This article reviews the current concepts of cardiac rhythm, including impulse generation, automaticity, and conduction in normal and diseased cardiac tissues. The mechanisms of arrhythmogenesis (abnormal automaticity and triggered events) and automatic modulation of ...
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Pharmacoeconomic Considerations in Antiarrhythmic Therapy
PharmacoEconomics, 1992Recently, the Cardiac Arrhythmia Suppression Trial (CAST) has focused attention on the morbidity and mortality that may be associated with pharmacological antiarrhythmic therapies. While the severity and frequency of adverse effects vary among the available agents, it is uncertain whether initial therapy with one agent is preferable to that with ...
P J, Podrid, R J, Arnold, D J, Kaniecki
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Risks and Benefits of Antiarrhythmic Therapy
New England Journal of Medicine, 1994Drug treatment of cardiac arrhythmias is not uniformly effective and frequently causes side effects. Recently, new data have become available that more clearly delineate the risks of antiarrhythmic-drug therapy. At the same time, establishing a benefit of treatment with these drugs has proved difficult. The potential benefits of antiarrhythmic therapy -
Alastair J.J. Wood, Dan M. Roden
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Atrial Fibrillation: Antiarrhythmic Therapy
Current Problems in Cardiology, 2014Atrial fibrillation is the most common cardiac arrhythmia and is associated with significant morbidity, mortality, and economic cost. Although the benefit of anticoagulation has been well described, control of the underlying rhythm disturbance can be achieved in various ways. Numerous therapeutic options exist and continue to be developed; however, the
Mitchell A, Psotka, Byron K, Lee
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Therapy with Investigational Antiarrhythmic Drugs
Medical Clinics of North America, 1984The investigational antiarrhythmic agents available for use in this country are predominantly class I drugs with local anesthetic membrane effects. These drugs are often used successfully to control arrhythmias refractory to treatment with the standard antiarrhythmic drugs.
R H, Mead, D C, Harrison
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Current antiarrhythmic therapy overview
Cardiovascular Drugs and Therapy, 1990Cardiac arrhythmias are commonplace in the Western world and vary in their degree of seriousness from benign to life threatening. In general, arrhythmias may be managed in one of five ways: reassurance only, physical maneuvers, antiarrhythmic drugs, implantable electronic devices, and surgical or transvascular ablation.
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Antiarrhythmic therapy in atrial fibrillation
Pharmacology & Therapeutics, 2010Currently available antiarrhythmic drugs for the management of AF are not sufficiently effective and are burdened with cardiac and extracardiac side effects that may offset their therapeutic benefits. Better knowledge about the mechanisms underlying generation and maintenance of AF may lead to the discovery of new targets for pharmacological ...
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New Approaches to Antiarrhythmic Therapy
New England Journal of Medicine, 1981Concepts of antiarrhythmic therapy have undergone major changes in the past decade for a variety of reasons. First of all, electrophysiologic studies — ushered in by the observation1 that His-bundle activation could be recorded simply, safely, and reliably in human beings — have progressed from academic, research-oriented tools providing important data
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