Results 1 to 10 of about 52,848 (330)

Repositioning of antiarrhythmics for prostate cancer treatment: a novel strategy to reprogram cancer-associated fibroblasts towards a tumor-suppressive phenotype [PDF]

Journal of Experimental & Clinical Cancer Research
Background Cancer-associated fibroblasts (CAFs) play a significant role in fueling prostate cancer (PCa) progression by interacting with tumor cells. A previous gene expression analysis revealed that CAFs up-regulate genes coding for voltage-gated cation
Valentina Doldi, Monica Tortoreto, Maurizio Colecchia, Massimo Maffezzini, Stefano Percio, Francesca Giammello, Federico Brandalise, Paolo Gandellini, Nadia Zaffaroni   +8 more
doaj   +3 more sources

Pediatric antiarrhythmics and toxicity: A clinical review

Journal of the American College of Emergency Physicians Open
Antiarrhythmic medications are fundamental in the acute and chronic management of pediatric arrhythmias. Particularly in the pediatric patient population, associated antiarrhythmic toxicities represent important potential adverse effects.
Alexandra T. Geanacopoulos, Benjamin Zielonka, Miriam T. Fox, Sarah Kerr, Kristina D. Chambers, Robert Przybylski, Michele M. Burns   +6 more
doaj   +2 more sources

Investigation of 1,4-Substituted 1,2,3-Triazole Derivatives as Antiarrhythmics: Synthesis, Structure, and Properties [PDF]

Pharmaceuticals, 2022
Here, we investigated the reaction of 1,3-dipolar cycloaddition of 1,3-diazido-2-nitro-2- azapropane (DANP) to propargyl alcohol over a copper-based catalyst and identified the optimum reaction conditions that enable the synthesis of 2-nitro-1,3-bis(4,4′-
Elena O. Shestakova, Sergey G. Il’yasov, Irina A. Shchurova, Vera S. Glukhacheva, Dmitri S. Il’yasov, Egor E. Zhukov, Arkady O. Bryzgalov, Tatiana G. Tolstikova, Yuri V. Gatilov   +8 more
doaj   +2 more sources

Efficacy of class III antiarrhythmics and magnesium combination therapy for atrial fibrillation

Pharmacy Practice, 2012
Atrial fibrillation is a common cardiac arrhythmia, and has been a significant financial burden. Class III antiarrhythmics such as dofetilide, ibutilide, and amiodarone are indicated for rhythm control.
Wang A
doaj   +2 more sources

Prenatally diagnosed fetal heart rhythm abnormalities—incidence, diagnosis and outcome

Clinical and Experimental Obstetrics & Gynecology, 2022
Backrounds: Fetal arrhythmias represent a significant cause of fetal morbidity and mortality and occur in approximately 1–3% of pregnancies. The unknown fetal arrhythmias are the cause of intrauterine fetal demise in as many as 3–10% of cases, as well as
Jelena Stamenković, Vojislav Parezanović, Olivera Kontić-Vučinić, Ivan Stefanović, Maja Trkulja, Ida Jovanović, Aleksandar Ljubić, Milena Srbinović   +7 more
doaj   +1 more source

Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits

JCI Insight, 2021
Native myocardial voltage-gated sodium (NaV) channels function in macromolecular complexes comprising a pore-forming (α) subunit and multiple accessory proteins.
Wandi Zhu, Wei Wang, Paweorn Angsutararux, Rebecca L. Mellor, L. Isom, J. Nerbonne, Jonathan R. Silva   +6 more
semanticscholar   +1 more source

Risk of interstitial lung disease in patients treated for atrial fibrillation with dronedarone versus other antiarrhythmics

Pharmacoepidemiology and Drug Safety, 2021
To compare risks of interstitial lung disease (ILD) between patients treated with dronedarone versus other antiarrhythmics.
A. Tave, E. Goehring, V. Desai, Chuntao Wu, R. Bohn, Sally Tamayo, N. Sicignano, J. Juhaeri, Judith K Jones, Sheila Weiss   +9 more
semanticscholar   +1 more source

Сardioprotective agents with biaromatic structure. Part 2. HCN channel blockers

Фармакокинетика и Фармакодинамика, 2022
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels, primarily their HCN4 subtype, are one of the promising targets for the development of cardioprotective agents.
G. V. Mokrov
doaj   +1 more source

Сardioprotective agents with biaromatic structure. Part 4. Potassium hERG channels blockers and modulators

Фармакокинетика и Фармакодинамика, 2023
The hERG subtype potassium channel (Kv11.1) is one of the most important and one of the most studied biological targets for the creation of cardioprotective agents.
G. V. Mokrov
doaj   +1 more source

Сardioprotective agents with biaromatic structure. Part 1. Calcium channel blockers

Фармакокинетика и Фармакодинамика, 2022
Cardiovascular diseases (CVD) are widespread and the leading cause of morbidity and mortality worldwide. Drugs for the treatment of CVD have been developed since the beginning of the 20th century.
G. V. Mokrov
doaj   +1 more source