Results 21 to 30 of about 1,859,987 (291)

Cyclic imide derivatives: As promising scaffold for the synthesis of antimicrobial agents

Journal of Research in Medical Sciences, 2018
Cyclic imides as building blocks in the synthesis of natural products, drugs and polymers display a diverse of pharmacological activities such as antibacterial, antifungal, anticonvulsant, anticancer, and anti-inflammatory effects. This review summarizes
Farshid Hassanzadeh, Elham Jafari
doaj   +1 more source

Rapid Quantification of Ceftobiprole in Human Plasma and Cerebrospinal Fluid by LC-MS/MS and Its Application in Patients with Central Nervous System Infections

Molecules
Ceftobiprole is a fifth-generation beta-cephalosporin with high inter-individual pharmacokinetic variability in critically ill patients. However, data on its pharmacokinetics and central nervous system (CNS) penetration are limited.
Sabahat Ablimit, Wanzhen Li, Mengting Chen, Jing Zhang, Nanyang Li, Yaxin Fan, Muyassar Yasen, Mubarak Iminjan, Beining Guo   +8 more
doaj   +1 more source

Mansonone G and its derivatives exhibit membrane permeabilizing activities against bacteria.

PLoS ONE, 2022
In an era where the rate of bacteria evolving to be resistant to clinically-used antibiotics far exceeds that of antibiotic discovery, the search for new sources of antibacterial agents has expanded tremendously.
Htut Htut Htoo, Nhung Ngo Thi Tuyet, Kittiporn Nakprasit, Chanat Aonbangkhen, Vorrapon Chaikeeratisak, Warinthorn Chavasiri, Poochit Nonejuie   +6 more
doaj   +1 more source

Pharmacokinetics, safety and population pharmacokinetics/pharmacodynamics analysis of meropenem-vaborbactam in Chinese healthy participants

Frontiers in Pharmacology
BackgroundMeropenem-vaborbactam is a fixed-dose β-lactam/β-lactamase inhibitor combination active against carbapenem-resistant Enterobacterales (CRE), especially Klebsiella pneumoniae carbapenemase (KPC)-producing CRE.
Wanzhen Li, Wanzhen Li, Qiong Wei, Mengting Chen, Mengting Chen, Xiaofen Liu, Xiaofen Liu, Beining Guo, Beining Guo, Yuancheng Chen, Qi Zhang, Wei Guan, Long Shen, Xiaohui Wang, Nanyang Li, Yan Chen, Yan Chen, Xin Li, Xin Li, Yingying Hu, Jing Zhang, Jing Zhang, Jing Zhang, Xiaojie Wu, Xiaojie Wu   +24 more
doaj   +1 more source

MOFs and MOF-Derived Materials for Antibacterial Application

Journal of Functional Biomaterials, 2022
Bacterial infections pose a serious threat to people’s health. Efforts are being made to develop antibacterial agents that can inhibit bacterial growth, prevent biofilm formation, and kill bacteria.
Xin Zhang, Feng Peng, Donghui Wang
doaj   +1 more source

Green synthesis of silver nanoparticles and their antibacterial effects

Frontiers in Chemical Engineering, 2022
Antibacterial resistance is by far one of the greatest challenges to global health. Many pharmaceutical or material strategies have been explored to overcome this dilemma.
Xiaoqian Xin, Chunli Qi, Chunli Qi, Liang Xu, Qin Gao, Xiaowen Liu   +5 more
doaj   +1 more source

Antibacterial, Anti-HIV-1 Protease and Cytotoxic Activities of Aqueous Ethanolic Extracts from Combretum Adenogonium Steud. Ex A. Rich (Combretaceae). [PDF]

, 2012
\ud \ud Records have shown that Combretum adenogonium Steud. Ex A. Rich (Combretaceae) is used in traditional medicine systems of several tribes in Tanzania. This study focused on the investigation of antibacterial activity, anti-HIV-1 protease activity,
Innocent Ester, Mbwambo, Z.H., Mushi Novatus F, Mbwambo Zakaria H, Tewtrakul Supinya, Mushi, Novatus F, Mushi, N.F., Innocent, E., Innocent, Ester, Tewtrakul, Supinya, Tewtrakul, S., Mbwambo, Zakaria H   +11 more
core   +1 more source

Assessment of drug hypersensitivity with non-irritating concentrations of antibacterial agents for allergic skin tests: a review [PDF]

, 2014
Hypersensitivity reactions to antibiotics are common with a prevalence of 6-10% of all adverse reactions. There is a lack of guidelines and standardization of skin tests for the screening of hypersensitivity to all antibiotics, in terms of the ...
M. C., Shivamurthy, H. V., Anuradha, Biswas,Pritam   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Antibacterial Activity of Copper Nanoparticles (CuNPs) against a Resistant Calcium Hydroxide Multispecies Endodontic Biofilm

Nanomaterials, 2021
Endodontic treatment reduces the amount of bacteria by using antimicrobial agents to favor healing. However, disinfecting all of the canal system is difficult due to its anatomical complexity and may result in endodontic failure.
Beatriz Rojas, Nicole Soto, Marcela Villalba, Helia Bello-Toledo, Manuel Meléndrez-Castro, Gabriela Sánchez-Sanhueza   +5 more
doaj   +1 more source