Results 1 to 10 of about 11,792 (118)

An Update Review of Approaches to Multiple Action-Based Antibacterials

Antibiotics, 2023
Many approaches are being pursued to address the major global health challenge posed by the increasing resistance of pathogenic bacteria to antibacterial agents.
John B Bremner
exaly   +3 more sources

Drug-mediated disruption of the aging gut microbiota and mucosal immune system [PDF]

Frontiers in Aging
The human gut microbiota is comprised predominantly of bacteria, and also includes archaea, fungi, and viruses. The gastrointestinal epithelium, mucosal barrier, and mucosal immune system balance protection against infection at mucosal entry points with ...
Lia Totleben, Joel Thomas, Daniel Austin
doaj   +2 more sources

Trends in bacterial sepsis incidence and mortality in France between 2015 and 2019 based on National Health Data System (Système National des données de Santé (SNDS)): a retrospective observational study

BMJ Open, 2022
Objective This study aims to provide a case definition of sepsis of presumed bacterial aetiology based on 10th revision of the International Classification of Diseases (ICD-10) codes, to assess trends in sepsis incidence and mortality between 2015 and ...
Christian Brun-Buisson, Didier Guillemot, Laurence Watier, Fanny Pandolfi   +3 more
doaj   +1 more source

One-year hospital readmission for recurrent sepsis: associated risk factors and impact on 1-year mortality—a French nationwide study

Critical Care, 2022
Background Sepsis is a complex health condition, leading to long-term morbidity and mortality. Understanding the risk factors for recurrent sepsis, as well as its impact on mid- and long-term mortality among other risk factors, is essential to improve ...
Fanny Pandolfi, Christian Brun-Buisson, Didier Guillemot, Laurence Watier   +3 more
doaj   +1 more source

Antibiotic prescriptions and risk factors for antimicrobial resistance in patients hospitalized with urinary tract infection: a matched case-control study using the French health insurance database (SNDS)

BMC Infectious Diseases, 2021
Background Antibiotic resistance is increasing among urinary pathogens, resulting in worse clinical and economic outcomes. We analysed factors associated with antibiotic-resistant bacteria (ARB) in patients hospitalized for urinary tract infection, using
Marion Opatowski, Christian Brun-Buisson, Mehdi Touat, Jérôme Salomon, Didier Guillemot, Philippe Tuppin, Laurence Watier   +6 more
doaj   +1 more source

Resistance to Critical Important Antibacterials in Staphylococcus pseudintermedius Strains of Veterinary Origin

Antibiotics, 2022
Staphylococcal infections represent a challenge in companion animals and hospitalized patients. This study aimed to assess the resistance of Staphylococcus pseudintermedius isolates, against a broad panel of antibacterials, including exclusive to human ...
Alessandro Bellato, Patrizia Robino, Maria Cristina Stella, Laura Scarrone, Daniela Scalas, Patrizia Nebbia   +5 more
doaj   +1 more source

Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and Stoichiometry

mBio, 2020
The continued rise in antibiotic resistance is precipitating a medical crisis. Bacteriophage (phage) has been hailed as one possible therapeutic option to augment the efficacy of antibiotics.
Carmen Gu Liu, Sabrina I. Green, Lorna Min, Justin R. Clark, Keiko C. Salazar, Austen L. Terwilliger, Heidi B. Kaplan, Barbara W. Trautner, Robert F. Ramig, Anthony W. Maresso   +9 more
doaj   +1 more source

Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY

Nature Communications, 2022
MraY is a membrane enzyme required for bacterial cell wall synthesis. Here, the authors modify sphaerimicins as antibacterials targeting it via structure-based design and synthesis through two key reactions, showing a platform for further development of ...
Takeshi Nakaya, Miyuki Yabe, Ellene H. Mashalidis, Toyotaka Sato, Kazuki Yamamoto, Yuta Hikiji, Akira Katsuyama, Motoko Shinohara, Yusuke Minato, Satoshi Takahashi, Motohiro Horiuchi, Shin-ichi Yokota, Seok-Yong Lee, Satoshi Ichikawa   +13 more
doaj   +1 more source

Metal Complexes with Schiff Bases as Antimicrobials and Catalysts

Inorganics, 2023
Complexes of Schiff bases (SBs) with metals are promising compounds exhibiting a broad range of applications, such as catalysts, polymers, dyes, and several biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic,
Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda, Federica Giuzio, Carmela Saturnino, Pasquale Longo, Maria Stefania Sinicropi   +7 more
doaj   +1 more source

Purchase and use of antimicrobials in the hospital sector of Vietnam, a lower middle-income country with an emerging pharmaceuticals market.

PLoS ONE, 2020
IntroductionAntimicrobial use is associated with emergence of antimicrobial resistance. We report hospital antimicrobial procurement, as a surrogate for consumption in humans, expenditure and prices in public hospitals in Vietnam, a lower middle-income ...
Vu Quoc Dat, Phan Khanh Toan, H Rogier van Doorn, C Louise Thwaites, Behzad Nadjm   +4 more
doaj   +1 more source