Results 91 to 100 of about 8,328,368 (232)

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Angewandte Chemie, EarlyView.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros   +5 more
wiley   +2 more sources

DIARRHEA IN EARLY LIFE: PROGRESS IN DIAGNOSIS AND CONTROL OF DISEASE [PDF]

, 2010
Diarrheal diseases occurring in early life (< 3 years) are an heterogeneous group of abnormalities including gastrointestinal infections, food hypersensitivity and allergy, immune dysregulation, and primary abnormalities of the enterocyte.
Terrin, Gianluca
core   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

3′-Sialyllactose ameliorates antibiotic-associated diarrhea by shaping unique gut microbiota and metabolite composition

Journal of Dairy Science
: 3′-Sialyllactose (3′-SL) is a naturally occurring prebiotic in milk, known to regulate intestinal microbiota and prevent diseases. However, the mechanisms through which 3′-SL alleviates antibiotic-associated diarrhea remain poorly understood.
Yi Shan, Xiaolin Huang, Xue Han, Yuju Yang, Miaomiao Zheng   +4 more
doaj   +1 more source

Role of Probiotics in Optimizing the Causal Treatment for Acute Peritonsillitis

Zdorovʹe Rebenka, 2016
The article deals with the management of patients with tonsillitis and its complications. When considering the aspects of the treatment, the attention was paid to the problem of antibiotic-associated diarrhea, and it was recommended to combine the use of
V.I. Popovych
doaj   +1 more source

Профилактика антибиотикоассоциированной диареи у детей лактосодержащим пробиотиком

, 2020
The data on the frequency of the spread of antibiotic-associated diarrhea (AAD) in children. A different incidence of AAD in children of different age groups, highest in children under the age of 3 years.The possibility of reducing the frequency of its ...
О. В. Кладова, O. V. Molochkova, A. A. Novokshonov, Н. Л. Гришкевич, N. L. Waltz, Н. Л. Вальтц, О. В. Молочкова, А. А. Новокшонов, N. L. Grishkevich, O. V. Kladova, Ю. В. Компаниец, Yu. V. Kompaniets   +11 more
core   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

THE CLINICAL POTENTIAL OF LINEX FORTE® IN SYSTEMIC ANTIBIOTIC THERAPY

Медицинский совет, 2017
The article tells about the prevalence and etiopathogenesis of antibiotic-associated diarrhea and the main pathogens focusing on Clostridium difficile. The methods of treatment of the disease are described.
E. Y. Plotnikova, Y. V. Zakharova, T. Y. Gracheva   +2 more
doaj   +1 more source