Phage-induced efflux down-regulation boosts antibiotic efficacy. [PDF]
PLoS PathogensThe interactions between a virus and its host vary in space and time and are affected by the presence of molecules that alter the physiology of either the host or the virus.
Samuel Kraus +15 more
doaj +4 more sources
The impact of bacterial purine metabolism on antibiotic efficacy [PDF]
npj Antimicrobials and ResistanceMetabolism plays a key role in the three antibiotic evasion strategies used by bacteria: tolerance, persistence and resistance. Modulation of purine metabolism is emerging as a common, and clinically relevant, contributor to tolerant and resistant ...
Claire E. Stevens +2 more
doaj +2 more sources
The Use of Acute Immunosuppressive Therapy to Improve Antibiotic Efficacy against Intracellular Staphylococcus aureus [PDF]
Microbiology Spectrum, 2022 Interactions between Staphylococcus aureus and the host immune system can have significant impacts on antibiotic efficacy, suggesting that targeting and modulating the immune response to S.
Jenna E. Beam +5 more
doaj +2 more sources
The Combination of Antibiotic and Non-Antibiotic Compounds Improves Antibiotic Efficacy against Multidrug-Resistant Bacteria. [PDF]
Int J Mol Sci, 2023 Bacterial antibiotic resistance, especially the emergence of multidrug-resistant (MDR) strains, urgently requires the development of effective treatment strategies. It is always of interest to delve into the mechanisms of resistance to current antibiotics and target them to promote the efficacy of existing antibiotics.
Xiao G, Li J, Sun Z.
europepmc +3 more sources
A Review of Antibiotic Efficacy in COVID-19 Control [PDF]
Journal of Immunology Research, 2023 Severe acute respiratory disease is associated with chronic secondary infections that exacerbate symptoms and mortality. So far, many drugs have been introduced to treat this disease, none of which effectively control the coronavirus.
Hamidreza Hekmat +5 more
doaj +2 more sources
Using Targeted Nano-Antibiotics to Improve Antibiotic Efficacy against Staphylococcus aureus Infections. [PDF]
Antibiotics (Basel), 2023 The poor bioavailability of antibiotics at infection sites is one of the leading causes of treatment failure and increased bacterial resistance. Therefore, developing novel, non-conventional antibiotic delivery strategies to deal with bacterial pathogens is essential.
Le H, Dé E, Le Cerf D, Karakasyan C.
europepmc +5 more sources
Assessment value of interleukin‐6, procalcitonin, and C‐reactive protein early kinetics for initial antibiotic efficacy in patients with febrile neutropenia: A prospective study [PDF]
Cancer MedicineBackground This study aims to investigate the early kinetics of interleukin 6 (IL‐6), procalcitonin (PCT), and C‐reactive protein (CRP) on initial antibiotic efficacy in hematological disorder patients with febrile neutropenia (FN). Methods A total of 40
Haifeng Zheng +7 more
doaj +2 more sources
Current Promising Strategies against Antibiotic-Resistant Bacterial Infections
Antibiotics, 2022 Infections caused by antibiotic-resistant bacteria (ARB) are one of the major global health challenges of our time. In addition to developing new antibiotics to combat ARB, sensitizing ARB, or pursuing alternatives to existing antibiotics are promising ...
Jinzhou Ye, Xinhai Chen
doaj +1 more source
Microbial environments confound antibiotic efficacy [PDF]
Nature Chemical Biology, 2011 The increasing prevalence of bacteria that are insensitive to our current antibiotics emphasizes the need for new antimicrobial therapies. Conventional approaches to antibacterial development that are based on the inhibition of essential processes seem to have reached the point of diminishing returns.
Henry H, Lee, James J, Collins
openaire +2 more sources
Bacterial Metabolism and Antibiotic Efficacy [PDF]
Cell Metabolism, 2019 Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic homeostasis are significant consequences of treatment. Here, we describe three postulates that collectively define antibiotic efficacy in the context of bacterial metabolism: (1) antibiotics alter the metabolic state of bacteria, which contributes to the ...
Stokes, Jonathan M. +3 more
openaire +2 more sources