Results 41 to 50 of about 237,028 (256)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

An expired ceftazidime antibiotic as an inhibitor for disintegration of copper metal in pickling HCl media

Journal of Materials Research and Technology, 2021
The disintegration of Cu metal in 1 mol/L HCl and the mitigating effect of the expired Ceftazidime antibiotic were studied. The inhibition efficacy of Ceftazidime depends on its concentration in the medium.
M.M. Kamel, Q. Mohsen, Z.M. Anwar, M.A. Sherif   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Human-Derived Fibrin Glue: In Vitro Antibacterial Effects and Antibiotic Permeation

Türk Oftalmoloji Dergisi, 2014
Objectives: This study investigated the in vitro antibacterial efficacy and antibiotic permeation of human-derived fibrin glue (FG). Materials and Methods: FG was prepared under sterile conditions by the Blood Bank of Gazi University Faculty of Medicine.
Erdem Yüksel, Fikret Akata, Nilay Yüksel, Hasan Ali Tufan, Bedia Dinç Mert   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Antibiotics modulate neoadjuvant therapy efficiency in patients with breast cancer: a pilot analysis

Scientific Reports, 2021
Mounting evidence suggests that microbiota dysbiosis caused by antibiotic administration is a risk factor for cancer, but few research reports focus on the relationships between antibiotics and chemotherapy efficiency.
Xi Zhang, Long Yu, Jiajie Shi, Sainan Li, Shiwei Yang, Wei Gao, Shan Yang, Meng Cheng, Haoqi Wang, Zhanjun Guo, Cuizhi Geng   +10 more
doaj   +1 more source

Antibiotic efficacy is linked to bacterial cellular respiration [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance The global burden of antibiotic resistance has created a demand to better understand the basic mechanisms of existing antibiotics. Of significant interest is how antibiotics may perturb bacterial metabolism, and how bacterial metabolism may influence antibiotic activity.
Michael A. Lobritz, Peter Belenky, Caroline B. M. Porter, Arnaud Gutierrez, Jason H. Yang, Eric G. Schwarz, Daniel J. Dwyer, Ahmad S. Khalil, James J. Collins   +8 more
openaire   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The public’s irrational use of antibiotics for upper respiratory tract infections: a cross-sectional study based on the health belief model

Scientific Reports
To understand the reasons for the public’s irrational use of antibiotics based on the health belief model (HBM). A questionnaire survey was conducted based on cluster random sampling in Chongqing, China.
Xi Wang, Chenxi Liu, Shuangjiang Zheng, Xinyi Zhang, Rujiao Lin, Lixia Duan, Dan Wang, Qianning Wang, Weidong Zhong, Xin Ding   +9 more
doaj   +1 more source