Results 11 to 20 of about 232,029 (258)
Combating Antibiotic Tolerance Through Activating Bacterial Metabolism
Frontiers in Microbiology, 2020 The emergence of antibiotic tolerance enables genetically susceptible bacteria to withstand the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence sheds light on the critical and underappreciated role of antibiotic
Yuan Liu +9 more
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The cystic fibrosis lung microenvironment alters antibiotic activity: causes and effects
European Respiratory Review, 2021 Chronic airway colonisation by Pseudomonas aeruginosa, a hallmark of cystic fibrosis (CF) lung disease, is associated with increased morbidity and mortality and despite aggressive antibiotic treatment, P. aeruginosa is able to persist in CF airways.
Sara Van den Bossche +4 more
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Antibiotic sensitivity of Rhodococcus equi in clinical specimens is correlated with efficacy of clinical treatment [PDF]
Jichu yixue yu linchuang, 2022 Objective To isolate and identify Rhodococcus equi(R.equi) from clinical specimens for potential relationship between antibiotic sensitivity and efficacy of antibiotic chemotherapy.
LI Jing
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mBio, 2022 Combination treatments are commonly prescribed for enhancing drug efficacy, as well as for preventing the evolution of resistance. The interaction between drugs is typically evaluated near the MIC, using growth rate as a measure of treatment efficacy ...
Jia-Feng Liu +5 more
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mBio, 2022 Mycobacterium tuberculosis segregates within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accumulation, and efficacy.
Pierre Santucci +7 more
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Microorganisms, 2021 Total joint arthroplasty (TJA) surgeries are common orthopedic procedures, but bacterial infection remains a concern. The aim of this study was to assess interactions between wear particles (WPs) and immune cells in vitro and to investigate if WPs affect
Claudia Siverino +7 more
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Antibiotic efficacy — context matters
Current Opinion in Microbiology, 2017 Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each contribute to antibiotic-induced ...
Yang, Jason Hung-Ying +2 more
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Safety and efficacy of glycopeptide antibiotics [PDF]
Journal of Antimicrobial Chemotherapy, 2005 It would be difficult to envision the practice of infectious diseases over the past 20 years without the availability of the glycopeptide antibiotics. The two agents currently in clinical use, vancomycin and teicoplanin, have proven remarkably versatile in many common applications. Several attributes of these agents account for this favourable profile:
R G, Finch, G M, Eliopoulos
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Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy. [PDF]
PLoS Biology, 2016 The lack of effective and well-tolerated therapies against antibiotic-resistant bacteria is a global public health problem leading to prolonged treatment and increased mortality.
Dilay Hazal Ayhan +7 more
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Applied Sciences, 2021 Antimicrobial resistance is one of the greatest threats to global health. Although the efforts in antibiotic drug discovery continue to play a pivotal role, this solution alone probably will not be enough to ensure the required level of infection control
Hung Le +4 more
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