Results 31 to 40 of about 232,029 (258)

Cold Plasma Deposition of Tobramycin as an Approach to Localized Antibiotic Delivery to Combat Biofilm Formation

Pathogens
Hospital-acquired infections (HAIs) remain a significant factor in hospitals, with implant surfaces often becoming contaminated by highly resistant strains of bacteria. Recent studies have shown that electrical plasma discharges can reduce bacterial load
Beatrice Olayiwola, Fiona O’Neill, Chloe Frewen, Darren F. Kavanagh, Rosemary O’Hara, Liam O’Neill   +5 more
doaj   +1 more source

Flagellar motility and the mucus environment influence aggregation-mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection

mBio
Pseudomonas aeruginosa routinely causes chronic lung infection in individuals with muco-obstructive airway diseases (MADs). In MADs, P. aeruginosa forms antibiotic-tolerant biofilm-like aggregates within hyperconcentrated airway mucus.
Matthew G. Higgs, Matthew A. Greenwald, Cristian Roca, Jade K. Macdonald, Ashelyn E. Sidders, Brian P. Conlon, Matthew C. Wolfgang   +6 more
doaj   +1 more source

Real-world efficacy and safety of cefepime for pediatric community-acquired pneumonia: a propensity score-matched study

Frontiers in Cellular and Infection Microbiology
ObjectiveThis study aimed to evaluate the real-world clinical efficacy and safety of cefepime in treating pediatric community-acquired pneumonia (CAP), comparing it with other broad-spectrum antibiotics, including cefoperazone-sulbactam and meropenem ...
Changxin Liu, Changxin Liu, Jiayu Deng, Yudi Xing, Yudi Xing, Yanqing Song, Yanqing Song   +6 more
doaj   +1 more source

Comparison Between the Combination Therapy in Terms of Therapeutic Effectiveness and Anti-Microbial Efficacy in Extensive Drug-Resistant Acinetobacter Baumannii Infections

Life and Science, 2023
Objective: To compare the clinical and antimicrobial efficacy of a triple-antibiotic regimen (Colistin, Cefoperazone/Sulbactam, and Tigecycline) with a double-antibiotic regimen (Colistin and Minocycline) for treating drug-resistant Acinetobacter ...
Naila Parveen, Rana Imran Sikander, Muhammad Zeeshan, Syed Muneeb Ali, Muhammad Hassan   +4 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In vitro activity of antibiotic monotherapy and combination therapy with bacteriophages against Staphylococcus aureus LVAD-driveline infections

Journal of Clinical Microbiology
Left-ventricular assist devices (LVADs) are increasingly used as a bridge to heart transplantation and destination therapy. These devices, especially the driveline, are susceptible to difficult-to-treat infections, associated with high morbidity and ...
Michèle M. Molendijk, Nelianne J. Verkaik, Corné P. de Vogel, Nicole Lemmens-den Toom, Gwenan M. Knight, Kadir Caliskan, Lonneke G. M. Bode, Annelies Verbon, Marion P. G. Koopmans, Miranda de Graaf, Willem J. B. van Wamel   +10 more
doaj   +1 more source

Preserving the efficacy of antibiotics to tackle antibiotic resistance

Microbial Biotechnology
Abstract Different international agencies recognize that antibiotic resistance is one of the most severe human health problems that humankind is facing. Traditionally, the introduction of new antibiotics solved this problem but various scientific and economic reasons have led to a shortage of novel antibiotics at the pipeline.
Pablo Laborda, Teresa Gil‐Gil, José Luis Martínez, Sara Hernando‐Amado   +3 more
openaire   +4 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

An expired ceftazidime antibiotic as an inhibitor for disintegration of copper metal in pickling HCl media

Journal of Materials Research and Technology, 2021
The disintegration of Cu metal in 1 mol/L HCl and the mitigating effect of the expired Ceftazidime antibiotic were studied. The inhibition efficacy of Ceftazidime depends on its concentration in the medium.
M.M. Kamel, Q. Mohsen, Z.M. Anwar, M.A. Sherif   +3 more
doaj   +1 more source