Results 141 to 150 of about 4,390,699 (400)

Characterization of Enterobacterales growing on selective CPE screening plates with a focus on non-carbapenemase-producing strains

Microbiology Spectrum
Carbapenem-resistant Enterobacterales (CRE) are divided into two distinct groups: carbapenemase-producing (CPE) and non-carbapenemase-producing (non-CPE).
Reut Efrati Epchtien, Elizabeth Temkin, Mor N. Lurie-Weinberger, Ophir Kastel, Alona Keren-Paz, David Schwartz, Yehuda Carmeli   +6 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Bacteriophages (“phages,” viruses that infect bacteria) are an important source of selection for bacterial populations. Phages use various structures to infect bacterial cells, and bacteria often evolve phage resistance by losing or ...
A. R. Burmeister, Abigail Fortier, C. Roush, Adam J Lessing, R. Bender, Roxanna Barahman, Raeven Grant, B. Chan, P. Turner   +8 more
semanticscholar   +1 more source

Characterizing Scales of Genetic Recombination and Antibiotic Resistance in Pathogenic Bacteria Using Topological Data Analysis

, 2014
Pathogenic bacteria present a large disease burden on human health. Control of these pathogens is hampered by rampant lateral gene transfer, whereby pathogenic strains may acquire genes conferring resistance to common antibiotics. Here we introduce tools
A. Holzinger, C. Fraser, C.M. Thomas, C.R. Woese, F. Meyer, G. Carlsson, H. Ochman, H. Rohde, H.C. Neu, J.E. Cooper, J.M. Chan, K.A. Jolley, M.O. Sommer, T. Dagan   +13 more
core   +1 more source

Translating a Preclinically Tested 15 Hz rTMS Protocol to Humans With Chronic Spinal Cord Injury: A Safety and Feasibility Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Repetitive transcranial magnetic stimulation (rTMS) is a non‐invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinically tested high‐frequency (15 Hz) rTMS (15 Hz rTMS) protocol was shown to induce corticospinal tract axon regeneration growth ...
Nabila Brihmat, Mehmed B. Bayram, Morgan Paine, Janelle Carnahan, Jian Zhong, Xiaofei Guan, Guang H. Yue, Soha Saleh, Gail F. Forrest   +8 more
wiley   +1 more source

Airborne Multidrug-Resistant Bacteria Isolated from a Concentrated Swine Feeding Operation [PDF]

, 2004
The use of nontherapeutic levels of antibiotics in swine production can select for antibiotic resistance in commensal and pathogenic bacteria in swine. As a result, retail pork products, as well as surface and groundwaters contaminated with swine waste ...
Amy Chapin, Ana Rule, Jensen LB, Kellogg Schwab, Kristen Gibson, Mackiewicz B, Timothy Buckley, Zahn JA   +7 more
core   +2 more sources

Antibiotic Resistance

, 2019
Microbes are known to exist since antiquity. Many antibiotics are obtained from soil microbes (fungi and bacteria) and have been present in the environment long before humans started using them in clinical settings. Microorganisms have been naturally exposed to these bioactive products during evolution.
Gurudas Khilnani, Ajeet Kumar Khilnani
openaire   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets

BMC Genomics, 2017
Background Fluoroquinolones are broad-spectrum antibiotics used to prevent and treat a wide range of bacterial infections. Plasmid-mediated qnr genes provide resistance to fluoroquinolones in many bacterial species and are increasingly encountered in ...
Fredrik Boulund, Fanny Berglund, Carl-Fredrik Flach, Johan Bengtsson-Palme, Nachiket P. Marathe, DG Joakim Larsson, Erik Kristiansson   +6 more
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source