Results 211 to 220 of about 2,829,471 (309)

Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases. [PDF]

Proc Natl Acad Sci U S A
Kelly ETR, Myziuk I, Hemmings MZ, Mulla Z, Blanchet J, Ruzzini A, Berghuis AM.   +6 more
europepmc   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland

International Journal of Infectious Diseases, 2016
Nadia Liassine, Laetititia Assouvie, Marie-Christine Descombes, Valérie Dénervaud Tendon, Nicolas Kieffer, Laurent Poirel, Patrice Nordmann   +6 more
doaj   +1 more source

Modulation of rob expression accelerates development of antibiotic resistance in Yersinia enterocolitica. [PDF]

Nucleic Acids Res
Wang X, Chen T, Jonker M, de Koster A, de Leeuw W, Ter Kuile BH, Dugar G.   +6 more
europepmc   +1 more source

Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation

Advanced Science, EarlyView.
Lipid nanostructured particles with increasing negative Gaussian curvature progress from vesicles to P‐cubosomes and D‐cubosomes. This curvature hierarchy enhances interaction with bacterial membranes, promotes membrane remodeling and leakage, and potentiates daptomycin activity against MRSA.
Xiangfeng Lai, Shuhong Wang, Chenguang Ding, Xenia Kostoulias, Anton P. Le Brun, Hsien‐Yi Hsu, Jhih‐Hang Jiang, Yajun Wang, Richard A. Strugnell, Anton Y. Peleg, Hsin‐Hui Shen   +10 more
wiley   +1 more source

Uncovering an alternate pathway of antibiotic resistance in spore-forming bacteria. [PDF]

Nat Commun
Srikhanta YN, Bate CE, Ng D, Revitt-Mills SA, Gilmore GR, Williams GC, Day SL, Mesnage S, Kochan K, Shrestha S, Shen A, Knight DR, Imwattana K, Riley TV, Alevizos I, Bourke K, Awad MM, Evans CA, Siddiqui G, Steele JR, Steer DL, Morrow JP, Creek DJ, Webb C, McGowan S, Lyras D.   +25 more
europepmc   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Isolation and characterization of bacteriophages against antibiotic-resistance <i>Pseudomonas aeruginosa</i>. [PDF]

Iran J Microbiol
Elkhichi PA, Bahonar S, Shirazi H, Bahramian A, Aghdam MK, Ghazi M.   +5 more
europepmc   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Severity-dependent alterations in oral microbiota and antibiotic resistance in children with dental fluorosis. [PDF]

J Oral Microbiol
Xia Y, Peng S, Yu J, Wang Y, Ye Y, Liu M, Shang L, Cui X, Wang P, Ding Z.   +9 more
europepmc   +1 more source