Results 251 to 260 of about 2,829,471 (309)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Development and Evaluation of Liposomal Nanobiotics for Combating Antibiotic Resistance Among Enterobacteriaceae. [PDF]

Int J Nanomedicine
Devi T B, K V DF, Kini S, Deekshit VK.
europepmc   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Analysis of the Etiology and Antibiotic Resistance of Bacterial Infections in Newborns in a Chinese Tertiary Hospital: From 2019 to 2024. [PDF]

Infect Drug Resist
Sun H, Luo J.
europepmc   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Global transmission dynamics of antibiotic resistance genes: Foodborne pathways as the critical link to humans. [PDF]

One Health
Odinga ES, Ohore OE, Zhou S, Ziyu Z, Hongrui Z, Yang G.   +5 more
europepmc   +1 more source

Lack of Knowledge and Training About Antibiotic Resistance Among Community Pharmacists in Bangladesh: A Cross-Sectional Study. [PDF]

Health Sci Rep
Hossain MJ, Shahariar M, Barsha LHJ, Shahjahan M, Towhid ST, Sheikh MK, Hasan MM, Rahaman MH, Sazid MS.   +8 more
europepmc   +1 more source

<i>In silico</i> drug discovery pipelines targeting antibiotic resistance: from genomes to leads. [PDF]

Front Bioinform
Gupta R, Singh P, Ravi K, Abomughaid MM, Lakhanpal S, Sharma R, Kumar N, Jha NK.   +7 more
europepmc   +1 more source

Prevalence and associations of antibiotic resistance and biofilm formation with molecular determinants in clinical Acinetobacter baumannii isolates. [PDF]

Sci Rep
Abu-Resha AM, Saleh HH, Abou-Dobara MI, El-Sayed AK.   +3 more
europepmc   +1 more source