Results 61 to 70 of about 3,847,992 (256)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Metagenome-Wide Analysis of Rural and Urban Surface Waters and Sediments in Bangladesh Identifies Human Waste as a Driver of Antibiotic Resistance

mSystems, 2021
In many low- and middle-income countries, antibiotic-resistant bacteria spread in the environment due to inadequate treatment of wastewater and the poorly regulated use of antibiotics in agri- and aquaculture.
Ross Stuart McInnes, Md Hassan uz-Zaman, Imam Taskin Alam, Siu Fung Stanley Ho, Robert A. Moran, John D. Clemens, Md Sirajul Islam, Willem van Schaik   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Analysis of Antibiotic Resistance Genes (ARGs) across Diverse Bacterial Species in Shrimp Aquaculture [PDF]

There is little information available on antibiotic resistance (ABR) within shrimp aquaculture environments. The aim of this study was to investigate the presence of antibiotic resistance genes (ARGs) in shrimp farming operations in Atacames, Ecuador ...
Thomas VanderYacht, Salinas, Liseth, VanderYacht, Thomas, Tilden M. Mitchell, Graham, Jay P, Mitchell, Tilden M, Jay P. Graham, Ho, Tin, Trueba, Gabriel, Nikolina Walas, Gabriel Trueba, Liseth Salinas, Walas, Nikolina, Tin Ho   +13 more
core   +1 more source

Monitoring of Non-β-Lactam Antibiotic Resistance-Associated Genes in ESBL Producing Enterobacterales Isolates

, 2020
Genetic context of extended spectrum β-Lactamase (ESBL) producing Enterobacterales and its association with plasmid mediated quinolone resistance (PMQR), aminoglycoside modifying enzymes (AME) and Trimethoprim/Sulfamethoxazole (TMP-SMX) resistance ...
Snawar Hussain, Nagaraja Sreeharsha, Rajesh Bareja, Mahesh Attimarad, Anroop B. Nair, Katharigatta N. Venugopala, Pottathil Shinu, Vashishth Mishra, Sahibzada Tasleem Rasool   +8 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Combining Functional Genomics and Whole-Genome Sequencing to Detect Antibiotic Resistance Genes in Bacterial Strains Co-Occurring Simultaneously in a Brazilian Hospital

, 2021
(1) Background: The rise of multi-antibiotic resistant bacteria represents an emergent threat to human health. Here, we investigate antibiotic resistance mechanisms in bacteria of several species isolated from an intensive care unit in Brazil.
Felipe Marcelo Pereira-dos-Santos, Lucas Ferreira Ribeiro, Ana Flavia Tonelli Scaranello, Rafael Silva-Rocha, María-Eugenia Guazzaroni, Tiago Cabral Borelli, Livia Zaramela, Gabriel Lencioni Lovate   +7 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Two Different Tetracycline Resistance Mechanisms, Plasmid-Carried tet(L) and Chromosomally Located Transposon-Associated tet(M), Coexist in Lactobacillus sakei Rits 9 [PDF]

, 2008
Lactobacillus sakei is extensively used as functional starter culture in fermented meat products. One of the safety criteria of a starter culture is the absence of potentially transferable antibiotic resistance determinants.
González de los Reyes-Gavilán, Clara, Ammor, Mohammed Salim, Mayo, B., Danielsen, Morten, Zagorec, Monique, Ammor, M.S., Margolles Barros, Abelardo, Gueimonde, M., Reyes-Gavilán, C.G., de los, van Hoek, A.H.A.M., Hoek, A.H.A.M., van, Gueimonde Fernández, Miguel, de los Reyes-Gavilán, C.G., Mayo Pérez, Baltasar, H. A. M. van Hoek, Angela, Danielsen, M., Zagorec, M., Margolles, A.   +17 more
core   +1 more source

Antibiotic resistance of lactic acid bacteria isolated from dairy products in Tianjin, China

Journal of Agriculture and Food Research, 2019
Antibiotic resistance poses safety risk to public health. Limited studies have considered the spread of resistance due to bacteria used in food production.
Kaidi Wang, Hongwei Zhang, Jinsong Feng, Luyao Ma, César de la Fuente-Núñez, Shuo Wang, Xiaonan Lu   +6 more
doaj   +1 more source