Results 61 to 70 of about 253,773 (311)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Genetic Basis of Tetracycline Resistance in Bifidobacterium animalis subsp lactis

, 2010
All strains of Bifidobacterium animalis subsp. lactis described to date show medium level resistance to tetracycline. Screening of 26 strains from a variety of sources revealed the presence of tet(W) in all isolates. A transposase gene upstream of tet(W)
van Hoek, A.H.A.M., Hoek, A.H.A.M., van, de los Reyes-Gavilan, C.G., Stroman, P., Stuer-Lauridsen, B., Gueimonde, M., Reyes-Gavilan, C.G., de los, Florez, A.B., Margolles, A.   +8 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Antibiotics Resistance Genes

Ricos Biology
Antibiotic resistance has become one of the most pressing worldwide fitness issues, jeopardizing the effectiveness of contemporary medication. Resistance genes, commonly observed in cellular genetic factors such as plasmids, transposons, and integrons, are imperative to the spread of resistance across bacterial populations.
Rehan Haider, Geetha Kumari Das, Zameer Ahmed Khanzada, Sambreen Zameer Khanzada   +3 more
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

In silico analysis of antibiotic resistance genes in Lactiplantibacillus plan‐ tarum subsp. plantarum Kita‐3

Indonesian Journal of Biotechnology, 2023
The absence of transferable antibiotic resistance genes is required for the safety of commercial probiotics. Previous studies have found that antibiotic resistance genes on plasmids in Lactobacilli make them unsafe for food purposes due to the genes ...
Angelia Wattimury, Dian Anggraini Suroto, Tyas Utami, Rachma Wikandari, Endang Sutriswati Rahayu   +4 more
doaj   +1 more source

Diversity analysis of Streptomycetes and associated phosphotranspherase genes in soil [PDF]

, 2012
An attempt was made to verify the observation that Streptomyces griseus was prevalent in soil based on isolation work. A genus-specific PCR was developed for Streptomyces based on the housekeeping gene atpD and used to investigate species diversity ...
Paris Laskaris, Takuya Sekine, Laskaris Paris, Sekine Takuya, Elizabeth M H Wellington, Sekine, Takuya, Wellington, E. M. H., Laskaris, Paris, Wellington Elizabeth M. H.   +8 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Antibiotic resistance of lactic acid bacteria isolated from dairy products in Tianjin, China

Journal of Agriculture and Food Research, 2019
Antibiotic resistance poses safety risk to public health. Limited studies have considered the spread of resistance due to bacteria used in food production.
Kaidi Wang, Hongwei Zhang, Jinsong Feng, Luyao Ma, César de la Fuente-Núñez, Shuo Wang, Xiaonan Lu   +6 more
doaj   +1 more source

Suggestions for Management and Control of Antibiotics in Farmland Soil in China

中国工程科学, 2021
Antibiotics are important for sustaining the livestock and poultry industry in China; however, duo to the agricultural utilization of livestock and poultry manure, the risk of antibiotic resistance transmission becomes increasingly prominent.
Wang Na , Guo Xinyan , Shan Zhengjun , Cai Daoji   +3 more
doaj   +1 more source