Results 61 to 70 of about 410,112 (309)
Vancomycin gene selection in the microbiome of urban Rattus norvegicus from hospital environment [PDF]
, 2016 Background and objectives: Widespread use of antibiotics has resulted in selection pressure on genes that make bacteria non-responsive to antibiotics. These antibiotic-resistant bacteria are currently a major threat to global health.
Andersen, Paal Skytt +9 more
core +2 more sources
Horizontal Gene Transfer of Antibiotic Resistance Genes in Biofilms
Antibiotics, 2023 Most bacteria attach to biotic or abiotic surfaces and are embedded in a complex matrix which is known as biofilm. Biofilm formation is especially worrisome in clinical settings as it hinders the treatment of infections with antibiotics due to the facilitated acquisition of antibiotic resistance genes (ARGs).
Claudia Michaelis, Elisabeth Grohmann
openaire +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Indonesian Journal of Biotechnology, 2023 The absence of transferable antibiotic resistance genes is required for the safety of commercial probiotics. Previous studies have found that antibiotic resistance genes on plasmids in Lactobacilli make them unsafe for food purposes due to the genes ...
Angelia Wattimury +4 more
doaj +1 more source
Molecular epidemiological study of clinical Acinetobacter baumannii isolates: phenotype switching of antibiotic resistance [PDF]
, 2013 BackgroundThe presence of clinical Acinetobacter baumannii (A. baumannii) isolates with differing antibiotic resistance phenotypes in the same patient causes difficulties and confusion in treatment.
Chang-Hua Chen, Chieh-Chen Huang
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
In vivo selection of resistant E. coli after ingestion of milk with added drug residues. [PDF]
, 2014 Antimicrobial resistance represents a major global threat to modern medicine. In vitro studies have shown that very low concentrations of drugs, as frequently identified in the environment, and in foods and water for human and animal consumption, can ...
Bicalho, Rodrigo Carvalho +3 more
core +6 more sources
Suggestions for Management and Control of Antibiotics in Farmland Soil in China
中国工程科学, 2021 Antibiotics are important for sustaining the livestock and poultry industry in China; however, duo to the agricultural utilization of livestock and poultry manure, the risk of antibiotic resistance transmission becomes increasingly prominent.
Wang Na +3 more
doaj +1 more source
Bacterial evolution: Resistance is a numbers game [PDF]
, 2016 Plasmids are well known for spreading antibiotic-resistance genes between bacterial strains. Recent experiments show that they can also act as catalysts for evolutionary innovation, promoting rapid evolution of novel antibiotic ...
A San Millan +7 more
core +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source