Results 131 to 140 of about 244,603 (309)

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus.

, 2015
There is a growing concern by regulatory authorities for the selection of antibiotic resistance caused by the use of biocidal products. We aimed to complete the detailed information on large surveys by investigating the relationship between biocide and ...
Orefici, Graziella, Oggioni, M.R., J. L. Martinez (7651718), G. Orefici (7619027), Oggioni, Marco R, Morrissey, I., M. Coque, T., Martinez, Jose-Luis, Freitas, Ana Teresa, Furi, L., Leib, Stephen, Knight, D.R., I. Morrissey (7636559), Orefici, G., BIOHYPO consortium (7653908), Coque, Teresa M, J. R. Coelho (7653899), Viti, C., Viti, Carlo, C. Viti (472695), A. T. Freitas (7653902), Morrissey, Ian, Rosado Coelho, J., Martinez, J-L, D. R. Knight (7636556), L. Furi (7636547), Knight, Daniel R, Teresa Freitas, A., BIOHYPO consortium,, Coelho, Joana Rosado, T. M. Coque (7653905), Marco R. Oggioni (131416), Furi, Leonardo   +32 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Antibiotic susceptibility to diverse antimicrobial agents.

, 2019
Antibiotic susceptibility to diverse antimicrobial agents.
Min Joo Choi (4532314), Ji Yun Noh (409863), Hee Jin Cheong (409860), Saem Na Lee (5040260), Joon Young Song (409859), Woo Joo Kim (409870), Min Ja Kim (575028), Ye Seul Jang (6278087), Eun Hwa Choi (781369), Hoan Jong Lee (781370)   +9 more
core   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi

, 2011
Eva Sapi1, Navroop Kaur1, Samuel Anyanwu1, David F Luecke1, Akshita Datar1, Seema Patel1, Michael Rossi1, Raphael B Stricker21Lyme Disease Research Group, Department of Biology and Environmental Sciences, University of New Haven, New Haven, CT, USA ...
Luecke DF, Sapi E, Anyanwu S, Stricker RB, Datar A, Patel S, Kaur N, Rossi M   +7 more
core  

Antibiotic susceptibility of IPD strains.

, 2014
a. Antibiotic susceptibility to different antibiotic classes. Black – resistant, Grey – intermediate, White – susceptible. b. Serotype distribution of isolates with penicillin MIC≥2 µg/ml, Blue shades- VT7 strains, Red shades – strains covered by PCV13 ...
Jacob Strahilevitz (520952), Klaris Riesenberg (384538), Ron Dagan (57723), Michal Stein (520953), Yonit Wiener-Well (520951), Galia Rahav (311303), Israel Potasman (520956), Gili Regev-Yochay (311310), Gabriel Weber (520955), Daniel Glikman (520954)   +9 more
core   +1 more source

Large‐Scale Quantitative Morphometry of Platelet α‐Granules via SIM Super‐Resolution Microscopy for Cancer Liquid Biopsy

Advanced Science, EarlyView.
ABSTRACT Blood‐based liquid biopsies hold transformative potential for non‐invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating diverse cancer‐associated responses, represent a compelling yet largely unexplored alternative.
Yan Ma, Huan Deng, Zelin Liu, Simei Zhong, Liangliang Wang, Mu He, Ning Jing, Lihua Dai, Yuzhen Basang, Xiao‐Yu Hu, Changyi Zhang, Huimin Zeng, Haoren Shao, Zhe Yang, Shanshan Zhao, Xiaohai Hu, Chuanjie Zhang, Xiaowei Wu, Jing Xu, Shaoqun Zeng, Jing Yuan, Qiang Li, Ziwei Qu, Zhenya Hong, Lingjuan Chen, Hanhua Dong, Jia Guo, Zhiqiang Han, Yu‐Hui Zhang   +28 more
wiley   +1 more source

Trends in prevalence and antibiotic non-susceptibility of Acinetobacter baumannii–calcoaceticus complex in Thailand (2000–2022): A secondary data analysis

Journal of Global Antimicrobial Resistance
Objectives: Antimicrobial resistance (AMR) is a significant global health concern. Due to its high prevalence in nosocomial infections and its increasing resistance to multiple antibiotics, Acinetobacter baumannii–calcoaceticus complex (ABC) is listed as
Panisara Kasemteerasomboon, Wiriya Mahikul, Nontaphat Leerach, Peerapon Siripongwutikorn, Kulsumpun Krobanan, Phimrata Leethongdee, Watcharaporn Kamjumphol, Aekkawat Unahalekhaka, Nuntaporn Rukluarh, Supalerk Sreesuk, Jiraphan Premsuriya   +10 more
doaj   +1 more source