Results 41 to 50 of about 384,617 (304)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Influence of Nutrient Media Compared to Human Synovial Fluid on the Antibiotic Susceptibility and Biofilm Gene Expression of Coagulase-Negative Staphylococci In Vitro

Antibiotics, 2021
Bacterial antibiotic resistance and biofilm formation are mechanisms usually involved in the pathogeny of implant-related infections. Worldwide, antibiotic susceptibility tests are usually carried out using nutrient-rich media.
Stephan Josef Maria Steixner, Christopher Spiegel, Dietmar Dammerer, Alexander Wurm, Michael Nogler, Débora Cristina Coraça-Huber   +5 more
doaj   +1 more source

Social interactions in the Burkholderia cepacia complex : biofilms and quorum sensing [PDF]

, 2010
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B.
Coenye, Tom
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Over-Expression of Hypochlorite Inducible Major Facilitator Superfamily (MFS) Pumps Reduces Antimicrobial Drug Susceptibility by Increasing the Production of MexXY Mediated by ArmZ in Pseudomonas aeruginosa

Frontiers in Microbiology, 2021
Pseudomonas aeruginosa, a well-known cause of nosocomial infection, is frequently antibiotic resistant and this complicates treatment. Links between oxidative stress responses inducing antibiotic resistance through over-production of RND-type efflux ...
Punyawee Dulyayangkul, Punyawee Dulyayangkul, Naphat Satapoomin, Matthew B. Avison, Nisanart Charoenlap, Paiboon Vattanaviboon, Paiboon Vattanaviboon, Skorn Mongkolsuk   +7 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Etiologic profile and antimicrobial susceptibility of community-acquired urinary tract infection in two Cameroonian towns

BMC Research Notes, 2012
Background Urinary tract infection (UTI) represents one of the most common diseases encountered in community medical practice. In resource poor settings, treatment is usually empiric due to the high cost and long duration required for reporting diagnosis
Akoachere Jane-Francis Tatah, Yvonne Suylika, Akum Njom, Seraphine Esemu   +3 more
doaj   +1 more source

Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition

Frontiers in Microbiology, 2021
Given its excellent performance against the pathogens, UV disinfection has been applied broadly in different fields. However, only limited studies have comprehensively investigated the response of bacteria surviving UV irradiation to the environmental ...
Hai-bei Li, Ai-ming Hou, Tian-jiao Chen, Dong Yang, Zheng-shan Chen, Zhi-qiang Shen, Zhi-gang Qiu, Jing Yin, Zhong-wei Yang, Dan-yang Shi, Hua-ran Wang, Jun-wen Li, Min Jin   +12 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rapid antimicrobial susceptibility testing in patients with bacteraemia due to Enterobacterales: an implementation study

Swiss Medical Weekly, 2023
AIMS OF THE STUDY: The goal of this descriptive study was to assess the performance as well as the extent of the clinical impact of rapid automated antimicrobial susceptibility testing in patients with bacteraemia due to Enterobacterales.
Claudine Reiber, Elias Bodendoerfer, Silvio D. Brugger, Nadia Eberhard, Eva Hitz, Daniel A. Hofmaenner, Sebastian Herren, Natalia Kolesnik-Goldmann, Stefano Manicini, Reinhard Zbinden, Annelies S. Zinkernagel, Barbara Hasse   +11 more
doaj   +1 more source