Results 91 to 100 of about 119,543 (251)

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

New antibiotic susceptibility testing definitions: «I» no longer means intermediate susceptibility

Anales de Pediatría (English Edition), 2022
David Aguilera-Alonso, Leticia Martínez Campos, Cecilia M. Fernández Llamazares, Cristina Calvo, Fernando Baquero-Artigao, Fernando Baquero Artigao, Leticia Martínez Campos, Carlos Rodrigo Gonzalo de Liria, José Tomás Ramos Amador, Cristian Launes Montaña, María Carmen Suarez Arrabal, Luis Escosa García, Susana Melendo Pérez, David Aguilera Alonso, Walter Goycoechea Valdivia, Eneritz Velasco Arnaiz, Cristina Epalza Ibarrondo, Marta García Ascaso   +17 more
doaj   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Proficiency Testing of Clinical Laboratories for Bacteriology in the Philippines, 2009–2015

Philippine Journal of Pathology, 2017
Introduction. SThe National External Quality Assessment Scheme (NEQAS) has been established by the Department of Health–Philippines (DOH) to provide DOH-approved external quality assessment programs, including the Proficiency Test (PT) for Bacteriology ...
Melisa Mondoy, Julius Matt Rapanut, Mark Philip Bugayong, Razaele Aguinaldo, Rafael Navarro, Kristine Jeanne Yap, Ma. Theresa Kapawan, Daryl Joy Almonia, Grace Esparar, Alexander Sadiasa, Noel Macalalad, Lydia Sombrero, Maria Rosario Capeding, Socorro Lupisan   +13 more
doaj  

Discrepancy between reference phenotypic and genotypic detection of cphA metallo-β-lactamase in Aeromonas spp.

Journal of Clinical Microbiology
Infection with Aeromonas spp. can be difficult to treat due to the common presence of multiple β-lactamase genes. Although the presence of β-lactamase genes appears to be mostly species-specific, species-level identification of Aeromonas spp.
Benjamin von Bredow, Marisol Trejo, Kevin W. Ward, Kevin P. Trieu, Cynthia A. Santellan, Omai B. Garner, Shangxin Yang, Sukantha Chandrasekaran   +7 more
doaj   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

Routine Susceptibility Testing of Helicobacter pylori in Clinical Practice—Results of a Prospective Multicentre Study

Antibiotics
Background/Objectives: Helicobacter pylori (HP) antibiotic eradication treatment in Germany is, at present, empirical according to the national guidelines.
Anke Hildebrandt, Farina Wewers, Lutz Uflacker, Barbara C. Kahl, Annika Hoyer, Reinhard Bornemann, Markus Brückner   +6 more
doaj   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Personalised antimicrobial susceptibility testing with clinical prediction modelling informs appropriate antibiotic use

Nature Communications
Antimicrobial susceptibility testing is a key weapon against antimicrobial resistance. Diagnostic microbiology laboratories use one-size-fits-all testing approaches that are often imprecise, inefficient, and inequitable.
Alex Howard, David M. Hughes, Peter L. Green, Anoop Velluva, Alessandro Gerada, Simon Maskell, Iain E. Buchan, William Hope   +7 more
doaj   +1 more source