Results 111 to 120 of about 126,613 (289)

Rapid identification and antimicrobial susceptibility testing reduce antibiotic use and accelerate pathogen-directed antibiotic use

, 2008
Introduction: Rapid bacterial identification and susceptibility tests can lead to earlier microbiological diagnosis and pathogen-directed, appropriate therapy.
Stijnen, Th. (Theo), Kerremans, Jos, Verbrugh, H.A. (Henri), Voss, A. (Andreas), Goessens, Wil, Stijnen, T (Theo), Hakkaart-van Roijen, L. (Leona), Hakkaart - van Roijen, Leona; id_orcid, Verboom, P (Paul), Vos, Greet, Verboom, P. (Paul), Goessens, W.H.F. (Wil), Vos, Greet; id_orcid, Kerremans, J.J. (Jos), Hakkaart - van Roijen, Leona, Verbrugh, Henri   +15 more
core   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

A multiplexed microfluidic platform for antibiotic susceptibility testing [PDF]

, 2014
Antibiotic susceptibility testing represents a key first step for determining therapeutic regimens to treat bacterial infections. Current technologies are slow and cumbersome, require large sample volumes for analysis, have poor detection sensitivity ...
Mohan, Ritika
core  

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Evaluation of the quickmic system in the rapid diagnosis of Gram-negative bacilli bacteremia

Microbiology Spectrum
Rapid microbiological diagnosis of the antibiotic susceptibility of Gram-negative bacilli is a priority in clinical microbiology, especially in cases of bacteremia.
Celia García-Rivera, Andrea Ricart-Silvestre, Mónica Parra Grande, María Paz Ventero, Iryna Tyshkovska-Germak, Antonia Sánchez-Bautista, Esperanza Merino, Juan Carlos Rodríguez   +7 more
doaj   +1 more source

Potential aquatic bacterial pathogens in the Philippines and Thailand : studies on the occurrence, characterisation, detection of potential virulence determinants and antimicrobial susceptibility profile

, 2004
Strains of Aeromonas spp., `non–cholera vibrios´(NCVs) and Plesiomonas shigelloides isolated from aquatic environments and fish and human diarrhoeal cases in the Philippines and Thailand were characterised for potential virulence markers, such as the ...
Maluping, Ramon
core  

Rapid Phenotypic Antibiotic Susceptibility Testing Through RNA Detection

, 2017
Background Culture-based antibiotic susceptibility testing, the gold standard, is too slow to guide early antibiotic selection, while newer genotypic methods require comprehensive knowledge of resistance mechanisms to predict phenotype.
Roby Bhattacharyya, Jonathan Livny, Jamin Liu, Deborah Hung, Peijun Ma, Nirmalya Bandyopadhyay   +5 more
core   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source