Results 121 to 130 of about 126,613 (289)

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Laboratory Diagnosis of Nosocomial Bacterial Infections Using Standard Methods

Medical Laboratory Journal, 2016
Background and objective: Implementation of standard methods for accurate detection of bacteria, correct antibiotic susceptibility testing and effective treatment of bacterial infections play important roles in development of public health and prevention
Saeideh Sadat Shobeiri, Saeid Abediankenari (Phd), Mohtaram Nasrollahi, Mohammad Khademlou, Maryam Sarabijamab   +4 more
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EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

New antibiotic susceptibility testing definitions: «I» no longer means intermediate susceptibility

Anales de Pediatría (English Edition), 2022
David Aguilera-Alonso, Leticia Martínez Campos, Cecilia M. Fernández Llamazares, Cristina Calvo, Fernando Baquero-Artigao, Fernando Baquero Artigao, Leticia Martínez Campos, Carlos Rodrigo Gonzalo de Liria, José Tomás Ramos Amador, Cristian Launes Montaña, María Carmen Suarez Arrabal, Luis Escosa García, Susana Melendo Pérez, David Aguilera Alonso, Walter Goycoechea Valdivia, Eneritz Velasco Arnaiz, Cristina Epalza Ibarrondo, Marta García Ascaso   +17 more
doaj   +1 more source

Discrepancy between reference phenotypic and genotypic detection of cphA metallo-β-lactamase in Aeromonas spp.

Journal of Clinical Microbiology
Infection with Aeromonas spp. can be difficult to treat due to the common presence of multiple β-lactamase genes. Although the presence of β-lactamase genes appears to be mostly species-specific, species-level identification of Aeromonas spp.
Benjamin von Bredow, Marisol Trejo, Kevin W. Ward, Kevin P. Trieu, Cynthia A. Santellan, Omai B. Garner, Shangxin Yang, Sukantha Chandrasekaran   +7 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Routine Susceptibility Testing of Helicobacter pylori in Clinical Practice—Results of a Prospective Multicentre Study

Antibiotics
Background/Objectives: Helicobacter pylori (HP) antibiotic eradication treatment in Germany is, at present, empirical according to the national guidelines.
Anke Hildebrandt, Farina Wewers, Lutz Uflacker, Barbara C. Kahl, Annika Hoyer, Reinhard Bornemann, Markus Brückner   +6 more
doaj   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Proficiency Testing of Clinical Laboratories for Bacteriology in the Philippines, 2009–2015

Philippine Journal of Pathology, 2017
Introduction. SThe National External Quality Assessment Scheme (NEQAS) has been established by the Department of Health–Philippines (DOH) to provide DOH-approved external quality assessment programs, including the Proficiency Test (PT) for Bacteriology ...
Melisa Mondoy, Julius Matt Rapanut, Mark Philip Bugayong, Razaele Aguinaldo, Rafael Navarro, Kristine Jeanne Yap, Ma. Theresa Kapawan, Daryl Joy Almonia, Grace Esparar, Alexander Sadiasa, Noel Macalalad, Lydia Sombrero, Maria Rosario Capeding, Socorro Lupisan   +13 more
doaj