Results 51 to 60 of about 126,613 (289)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Electrochemical Sensors for Antibiotic Susceptibility Testing: Strategies and Applications

Chemosensors, 2022
Increasing awareness of the impacts of infectious diseases has driven the development of advanced techniques for detecting pathogens in clinical and environmental settings.
Dongmin Kim, Seungmin Yoo
doaj   +1 more source

Assessment of antibiotic susceptibility of Legionella pneumophila isolated from water systems in Poland [PDF]

, 2017
Introduction and objective Several studies have reported therapy failures in patients with legionnaires’disease; however, antimicrobial resistance of clinical and environmental isolates of Legionella spp. has not yet been documented.
Sikora, Agnieszka, Bożena Krogulska, Iwona Gładysz, Kozioł-Montewka, Maria, Maria Kozioł-Montewka, Tomasz Stańczak, Wójtczak-Bobin, Małgorzata, Agnieszka Sikora, Gładysz, Iwona, Renata Matuszewska, Stańczak, Tomasz, Matuszewska, Renata, Małgorzata Wójtowicz-Bobin, Krogulska, Bożena   +13 more
core   +1 more source

Antibiotic Resistance, Susceptibility Testing and Stewardship in Helicobacter pylori Infection

, 2023
Despite the declining trend of Helicobacter pylori (H. pylori) prevalence around the globe, ongoing efforts are still needed to optimize current and future regimens in view of the increasing antibiotic resistance. The resistance of H. pylori to different
Ng, Ho Yu, Ka-Shing Cheung, Ho-Yu Ng, Leung, Wai K, Wai K. Leung, Cheung, Ka Shing   +5 more
core   +1 more source

Emerging technologies for antibiotic susceptibility testing

Biosensors and Bioelectronics, 2019
Superbugs such as infectious bacteria pose a great threat to humanity due to an increase in bacterial mortality leading to clinical treatment failure, lengthy hospital stay, intravenous therapy and accretion of bacteraemia. These disease-causing bacteria gain resistance to drugs over time which further complicates the treatment.
Behera, Bhagaban, Vishnu, Anil G K, Chatterjee, Suman, Sitaramgupta, V S N V, Sreekumar, Niranjana, Nagabhushan, Apoorva, Rajendran, Nirmala, Prathik, B H, Pandya, Hardik J   +8 more
openaire   +4 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Identification, characterization and antibiotic susceptibility testing for Bacillus species

Iranian Journal of Microbiology, 2022
Background and Objectives: With the increase in immunosuppressed patients and antimicrobial misuse, Bacillus species have risen as opportunistic pathogens in hospitalized patients.
Noha Alaa Eldin Fahim, Ghada Abd El-Wahed Ismail, Moataz Bellah Abdelaleem, Mervat Elanany, Sally Mohamed Saber, Marwa Abd EL-Rasoul EL-Ashry   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Antibiotic susceptibility testing and breakpoint determination [PDF]

Clinical Microbiology and Infection, 1996
To the Editors: Re: Phillips I . Clin Microbiol Infect 1995; l(1): 65-6 O n behalf of the Susceptibility Testing Working Party of the British Society for Antimicrobial Chemotherapy, I would like to endorse the views of the President of ESCMID in his aim to move to comparable susceptibility testing within Europe.
openaire   +2 more sources

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, Accepted Article.
Objective The objective is to describe and compare demographic, clinical and serological characteristics of systemic sclerosis (SSc) patients according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Canadian Scleroderma Research Group, M. Baron, M.Y. Choi, P. Docherty, P.R. Fortin, M. Fritzler, G. Gyger, S. Hoa, M. Hudson, A. Ikic, N. Jones, H. Kim, N. Khalidi, M. Larché, S. LeClercq, N. Maltez, A. Man, A. Masetto, J. Pope, D. Robinson, E. Sutton, C. Thorne, Sasha Bernatsky, Sabrina Hoa   +33 more
wiley   +1 more source