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BatR: A novel regulator of antibiotic tolerance inPseudomonas aeruginosabiofilms
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A dietary source of antibiotic tolerance
Cell Metabolism, 2021Antibiotic tolerance enables microorganisms to survive the exposure to antibiotics and serves as a precursor to antibiotic resistance. In a recent issue of Nature Microbiology, Liu et al. (2021) describe that high-fat-diet-induced changes in the intestinal microbiome and metabolome facilitate the development of antibiotic tolerance by bacterial ...
Patrick, Lundgren +2 more
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Tolerance to antibiotics affects response
Science, 2020Bacterial tolerance to antibiotics reduces the ability to prevent ...
Andrew D, Berti, Elizabeth B, Hirsch
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Antibiotic-induced disease tolerance
Nature Reviews Drug Discovery, 2020The tetracycline antibiotic doxycycline is shown to not only have direct antimicrobial effects but also promote disease tolerance mechanisms, including tissue repair and metabolic reprogramming.
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Microbial phenotypic heterogeneity and antibiotic tolerance
Current Opinion in Microbiology, 2007Phenotypic heterogeneity, defined as metastable variation in cellular parameters generated by epigenetic mechanisms, is crucial for the persistence of bacterial populations under fluctuating selective pressures. Diversity ensures that some individuals will survive a potentially lethal stress, such as an antibiotic, that would otherwise obliterate the ...
Neeraj, Dhar, John D, McKinney
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Tolerance of staphylococci to bactericidal antibiotics
Injury, 2006Antibiotic therapy for deep-seated staphylococcal infections, especially when they are associated with artificial devices used for orthopedic surgery is often associated with failure. Standard anti-staphylococcal bactericidal antibiotics, such as semi-synthetic penicillins, cephalosporins, or glycopeptides, are effective when given prophylactically in ...
Vaudaux, Pierre, Lew, Daniel Pablo
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Antibiotic Tolerance of Staphylococcus epidermidis
Scandinavian Journal of Infectious Diseases, 1985The phenomenon of antibiotic tolerance was studied in 50 strains of Staphylococcus epidermidis isolated from blood cultures. The antibiotics used for study were methicillin, nafcillin, oxacillin, cephalothin, cefazolin and vancomycin. The MICs and MBCs were determined in Mueller Hinton Broth (MHB) and Brain Heart Infusion broth (BHI) after incubation ...
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Antioxidant Strategies to Tolerate Antibiotics
Science, 2011Bacteria use two convergent strategies to combat toxic reactive oxygen species produced in response to antibiotic treatment.
Peter Belenky, James J. Collins
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Antibiotic tolerance facilitates the evolution of resistance
Science, 2017Resistance on a background of tolerance Bacteria survive antibiotic exposure either because they are quiescent when antibiotics are around in the highest concentrations (i.e., tolerance) or because they acquire active biochemical resistance mechanisms (i.e., resistance).
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