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Metal-containing landfills as a source of antibiotic tolerance

Environmental Monitoring and Assessment, 2023
To unveil the potential effect of metal presence to antibiotic tolerance proliferation, four sites of surface landfills containing tailings from metal processing in Slovakia (Hnúšťa, Hodruša, Košice) and Poland (Tarnowskie Góry) were investigated. Tolerance and multitolerance to selected metals (Cu, Ni, Pb, Fe, Zn, Cd) and antibiotics (ampicillin ...
M. Lachka   +8 more
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Antibiotic tolerance facilitates the evolution of resistance

Science, 2017
Resistance on a background of tolerance Bacteria survive antibiotic exposure either because they are quiescent when antibiotics are around in the highest concentrations (i.e., tolerance) or because they acquire active biochemical resistance mechanisms (i.e., resistance).
Levin-Reisman, Irit   +5 more
openaire   +2 more sources

Antibiotic Tolerance of Staphylococcus epidermidis

Scandinavian Journal of Infectious Diseases, 1985
The phenomenon of antibiotic tolerance was studied in 50 strains of Staphylococcus epidermidis isolated from blood cultures. The antibiotics used for study were methicillin, nafcillin, oxacillin, cephalothin, cefazolin and vancomycin. The MICs and MBCs were determined in Mueller Hinton Broth (MHB) and Brain Heart Infusion broth (BHI) after incubation ...
openaire   +2 more sources

Nonmultiplying Bacteria are Profoundly Tolerant to Antibiotics

2012
Bacteria survive treatments with antimicrobial agents; they achieve this in two ways. Firstly, bacteria quickly become tolerant to these agents. This tolerance is temporary, reversible, and associated with slowing of the multiplication rate. Secondly, bacteria can undergo genetic mutations leading to permanent clonal resistance to antimicrobial agents.
Yanmin, Hu, Anthony, Coates
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Antibiotic Tolerance in Producer Organisms

1979
Publisher Summary Antibiotics are found predominantly in the culture medium and not within the cells. This suggests that excretion is built into the biosynthetic process and, on present evidences, it is predicted that a mechanism to discourage reentry of the metabolite is an essential component in a majority of protective systems.
openaire   +2 more sources

Antioxidant Strategies to Tolerate Antibiotics

Science, 2011
Bacteria use two convergent strategies to combat toxic reactive oxygen species produced in response to antibiotic treatment.
Peter Belenky, James J. Collins
openaire   +1 more source

Biofilm-specific antibiotic tolerance and resistance

European Journal of Clinical Microbiology & Infectious Diseases, 2015
Biofilms are heterogeneous structures composed of bacterial cells surrounded by a matrix and attached to solid surfaces. The bacteria here are 100 to 1,000 times more tolerant to antimicrobials than corresponding planktonic cells. Biofilms can be difficult to eradicate when they cause biofilm-related diseases, e.g., implant infections, cystic fibrosis,
openaire   +2 more sources

Triclosan-tolerant bacteria: changes in susceptibility to antibiotics

Journal of Hospital Infection, 2009
There is no clear consensus regarding the effect of biocide tolerance on antibiotic susceptibility. In this work, triclosan-tolerant strains of Escherichia coli, Staphylococcus aureus and Acinetobacter johnsonii were compared with sensitive strains in order to ascertain their susceptibility to a range of antibiotics.
Cottell, A.   +4 more
openaire   +3 more sources

Antibiotic Tolerance and Resistance in Biofilms

2010
One of the most important features of microbial biofilms is their tolerance to antimicrobial agents and components of the host immune system. The difficulty of treating biofilm infections with antibiotics is a major clinical problem. Although antibiotics may decrease the number of bacteria in biofilms, they will not completely eradicate the bacteria in
Ciofu, Oana, Tolker-Nielsen, Tim
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Tolerability of Fluoroquinolone Antibiotics Past, Present and Future

Drug Safety, 1995
New fluoroquinolones have been in clinical use for 10 years and have an excellent record of safety and tolerance. The main elements of their adverse reaction profile were predictable from human experience with precursor naphthyridines and quinolones, and from toxicological studies in animals. Thus gastrointestinal reactions (1 to 5%), skin disturbances
P, Ball, G, Tillotson
openaire   +2 more sources

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