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Biofilm-specific antibiotic tolerance and resistance
European Journal of Clinical Microbiology & Infectious Diseases, 2015Biofilms are heterogeneous structures composed of bacterial cells surrounded by a matrix and attached to solid surfaces. The bacteria here are 100 to 1,000 times more tolerant to antimicrobials than corresponding planktonic cells. Biofilms can be difficult to eradicate when they cause biofilm-related diseases, e.g., implant infections, cystic fibrosis,
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Antibiotic Tolerance in Producer Organisms
1979Publisher Summary Antibiotics are found predominantly in the culture medium and not within the cells. This suggests that excretion is built into the biosynthetic process and, on present evidences, it is predicted that a mechanism to discourage reentry of the metabolite is an essential component in a majority of protective systems.
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Nonmultiplying Bacteria are Profoundly Tolerant to Antibiotics
2012Bacteria survive treatments with antimicrobial agents; they achieve this in two ways. Firstly, bacteria quickly become tolerant to these agents. This tolerance is temporary, reversible, and associated with slowing of the multiplication rate. Secondly, bacteria can undergo genetic mutations leading to permanent clonal resistance to antimicrobial agents.
Yanmin, Hu, Anthony, Coates
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Triclosan-tolerant bacteria: changes in susceptibility to antibiotics
Journal of Hospital Infection, 2009There is no clear consensus regarding the effect of biocide tolerance on antibiotic susceptibility. In this work, triclosan-tolerant strains of Escherichia coli, Staphylococcus aureus and Acinetobacter johnsonii were compared with sensitive strains in order to ascertain their susceptibility to a range of antibiotics.
Cottell, A. +4 more
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Antibiotic Tolerance and Resistance in Biofilms
2010One of the most important features of microbial biofilms is their tolerance to antimicrobial agents and components of the host immune system. The difficulty of treating biofilm infections with antibiotics is a major clinical problem. Although antibiotics may decrease the number of bacteria in biofilms, they will not completely eradicate the bacteria in
Ciofu, Oana, Tolker-Nielsen, Tim
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Tolerance to Anticoagulants During Antibiotic Therapy
Scandinavian Journal of Clinical and Laboratory Investigation, 1962(1962). Tolerance to Anticoagulants During Antibiotic Therapy. Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 14, No. 5, pp. 565-566.
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Antibiotic-TolerantStaphylococcus aureus
Laboratory Medicine, 1981In 1977, Sabath, et al., described a new type of penicillin resistance in strains of Staphylococcus aureus. These strains were inhibited by low concentrations of nafcillin, but high concentrations of this antibiotic were not lethal. The ratio of the minimum bactericidal concentration (MBC) to the minimum inhibitory concentration (MIC) varied from 128 ...
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Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward
Ca-A Cancer Journal for Clinicians, 2021Amila K Nanayakkara +2 more
exaly
Antibiotic resistance in the environment
Nature Reviews Microbiology, 2021D G Joakim Larsson, Carl-Fredrik Flach
exaly

