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Biofilm-specific antibiotic tolerance and resistance

European Journal of Clinical Microbiology & Infectious Diseases, 2015
Biofilms are heterogeneous structures composed of bacterial cells surrounded by a matrix and attached to solid surfaces. The bacteria here are 100 to 1,000 times more tolerant to antimicrobials than corresponding planktonic cells. Biofilms can be difficult to eradicate when they cause biofilm-related diseases, e.g., implant infections, cystic fibrosis,
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Antibiotic Tolerance in Producer Organisms

1979
Publisher Summary Antibiotics are found predominantly in the culture medium and not within the cells. This suggests that excretion is built into the biosynthetic process and, on present evidences, it is predicted that a mechanism to discourage reentry of the metabolite is an essential component in a majority of protective systems.
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Nonmultiplying Bacteria are Profoundly Tolerant to Antibiotics

2012
Bacteria survive treatments with antimicrobial agents; they achieve this in two ways. Firstly, bacteria quickly become tolerant to these agents. This tolerance is temporary, reversible, and associated with slowing of the multiplication rate. Secondly, bacteria can undergo genetic mutations leading to permanent clonal resistance to antimicrobial agents.
Yanmin, Hu, Anthony, Coates
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Triclosan-tolerant bacteria: changes in susceptibility to antibiotics

Journal of Hospital Infection, 2009
There is no clear consensus regarding the effect of biocide tolerance on antibiotic susceptibility. In this work, triclosan-tolerant strains of Escherichia coli, Staphylococcus aureus and Acinetobacter johnsonii were compared with sensitive strains in order to ascertain their susceptibility to a range of antibiotics.
Cottell, A.   +4 more
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Antibiotic Tolerance and Resistance in Biofilms

2010
One of the most important features of microbial biofilms is their tolerance to antimicrobial agents and components of the host immune system. The difficulty of treating biofilm infections with antibiotics is a major clinical problem. Although antibiotics may decrease the number of bacteria in biofilms, they will not completely eradicate the bacteria in
Ciofu, Oana, Tolker-Nielsen, Tim
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Tolerance to Anticoagulants During Antibiotic Therapy

Scandinavian Journal of Clinical and Laboratory Investigation, 1962
(1962). Tolerance to Anticoagulants During Antibiotic Therapy. Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 14, No. 5, pp. 565-566.
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Antibiotic-TolerantStaphylococcus aureus

Laboratory Medicine, 1981
In 1977, Sabath, et al., described a new type of penicillin resistance in strains of Staphylococcus aureus. These strains were inhibited by low concentrations of nafcillin, but high concentrations of this antibiotic were not lethal. The ratio of the minimum bactericidal concentration (MBC) to the minimum inhibitory concentration (MIC) varied from 128 ...
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Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward

Ca-A Cancer Journal for Clinicians, 2021
Amila K Nanayakkara   +2 more
exaly  

Antibiotic resistance in the environment

Nature Reviews Microbiology, 2021
D G Joakim Larsson, Carl-Fredrik Flach
exaly  

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