Results 61 to 70 of about 15,407,593 (258)

A mixed method approach to analysing patterns and drivers of antibiotic use and resistance in beef farms in Argentina

Frontiers in Veterinary Science
IntroductionAntimicrobial resistance is a challenge to be faced by all livestock sectors; within beef farming, antibiotic use patterns vary by country and management practices.
Cherrill Bedford, Maria Laura Galotta, Georgios Oikonomou, Guadalupe de Yaniz, Matías Nardello, Sergio Sánchez Bruni, Peers Davies   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Antibiotic resistance gene abundances correlate with metal and geochemical conditions in Scottish soils [PDF]

, 2011
The vast majority of antibiotic resistant genes (ARG) acquired by human pathogens have originated from the natural environment. Therefore, understanding factors that influence intrinsic levels of ARG in the environment could be epidemiologically ...
Brajesh K Singh, Seánı́n M. Mccluskey, Seánín M. McCluskey, Colin D Campbell, David W. Graham, Charles W. Knapp, Hudson, Gordon, Charles W Knapp, Gordon Hudson, David W Graham, Seánín M McCluskey, McCluskey, Seánín M., Campbell, Colin D., Graham, David W., Knapp, Charles W., Singh, Brajesh K., Brajesh K. Singh, Colin D. Campbell   +17 more
core   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Study of Molecular Mechanism of Antibiotic susceptibility against Polymicrobial Oral infection [PDF]

, 2010
Introduction- Antibiotic to treat dental caries infection are routinely prescribed. Bacteria have increased resistance to the currently recommended antibiotics.
Deepak Dwivedi
core  

"Practical Knowledge" and Perceptions of Antibiotics and Antibiotic Resistance Among Drugsellers in Tanzanian Private Drugstores. [PDF]

, 2010
Studies indicate that antibiotics are sold against regulation and without prescription in private drugstores in rural Tanzania. The objective of the study was to explore and describe antibiotics sale and dispensing practices and link it to drugseller ...
Mujinja, Phare, Tomson, G., Göran Tomson, Tomson, Göran, Kalala, W., Viberg, Nina, Kalala, Willbrord, Viberg, N., Lundborg Cecilia, Cecilia Stålsby Lundborg, Willbrord Kalala, Lundborg, Cecilia Stålsby, Mujinja, P., Lundborg, C.S., Phare Mujinja, Nina Viberg, Mujinja Phare, Viberg Nina, Tomson Göran, Kalala Willbrord   +19 more
core   +2 more sources

Pharmacovigilance Strategies to Address Resistance to Antibiotics and Inappropriate Use—A Narrative Review

Antibiotics
The spread of antimicrobial resistance (AMR) is a global challenge. Close and continuous surveillance for quick detection of AMR can be difficult, especially in remote places.
Valcieny Sandes, Albert Figueras, Elisangela Costa Lima   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Minimum Antibiotic Levels for Selecting a Resistance Plasmid in a Gnotobiotic Animal Model [PDF]

, 1989
The minimum antibiotic concentrations for selecting an R plasmid in vivo were determined in germfree rates colonized by two isogenic strains of Escherichia coli, one of which carried an R plasmid.
Lumeau, Solange, Corpet, Denis E., Corpet, Florence   +2 more
core  

Cluster randomised trial in the General Practice Research Database: 1. Electronic decision support to reduce antibiotic prescribing in primary care (eCRT study) [PDF]

, 2011
Background: the purpose of this research is to develop and evaluate methods for conducting cluster randomised trials in a primary care database that contains electronic patient records for large numbers of family practices.
Little Paul, Van Staa, Tjeerd; id_orcid, Ashworth, Maek, Delaney, Brendan, van Staa, Tjeerd, Gulliford Martin C, Moore Michael V, Judith Charlton, Paul Little, Gerard McCann, Gulliford, Martin C., Charlton, Judith, Little, Paul, Grieve, Andrew P, Ashworth Mark, Ashworth, Mark, Martin C Gulliford, Grieve Andrew P, Grieve, Andrew P., Van Staa, Tjeerd P., Dregan Alex, McCann, Gerard, Charlton Judith, electronic Cluster Randomised Trial Research Team eCRT Research, Taweel, Adel, Moore, Michael, Andrew P Grieve, Lucy Yardley, Mark Ashworth, Michael V Moore, Dregan, Alex; id_orcid, McCann Gerard, Tjeerd van Staa, Dregan, Alex, Yardley, Lucy, McDermott, Lisa, van Staa Tjeerd, null null, Electronic Cluster Randomised Trial Research Team eCRT Research Team, Wolfe, Charles, Lisa McDermott, Yardley Lucy, Gulliford, Martin C, Rudd, Anthony, Moore, Michael V, McDermott Lisa, Alex Dregan, Moore, Michael V.   +47 more
core   +2 more sources