Results 71 to 80 of about 15,407,593 (258)

ANTIBIOTIC RESISTANCE: PUBLIC KNOWLEDGE AND PERCEPTION OF ANTIBIOTIC USE IN RELATION TO SOCIAL DETERMINANTS

Pakistan Armed Forces Medical Journal, 2019
Objective: To assess the knowledge and perception of appropriate use of antibiotics, when to discontinue the course once the treatment begins and the conditions/illnesses antibiotics treat in relation to social determinants in residents of Wah.
Hina ` Shan, Syed Fawad Mashhadi, Saadia Maqbool   +2 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluating an audit and feedback intervention for reducing antibiotic prescribing behaviour in general dental practice (the RAPiD trial):a partial factorial cluster randomised trial protocol [PDF]

, 2014
Background: Antibiotic prescribing in dentistry accounts for 9% of total antibiotic prescriptions in Scottish primary care. The Scottish Dental Clinical Effectiveness Programme (SDCEP) published guidance in April 2008 (2nd edition, August 2011) for Drug ...
Ramsay, Craig R, Clarkson, Jan E.; id_orcid, Maria Prior, Elders, Andrew, Treweek, S, Elouafkaoui, P., Prior, M, Jan E Clarkson, Ramsay, CR, Translation Research in a Dental Setting (TRiaDS) Research Metho, Rumana Newlands, Ramsay, Craig, Bonetti, D, Stirling, D, Ramsay, C. R., Michie, S, Clarkson, J. E., Francis, J., Clarkson, Jan E, Vale, L, Elders, A., Clarkson, JE, null null, Pitts, N, Walker, A, Duncan, E. M., Clarkson, Jan, Francis, JJ, Prior, M., Grimshaw, JM, Young, Linda, Andrew Elders, Duncan, Eilidh M., Duncan, Eilidh, Black, I, Elders, A, Newlands, R., Duncan, EM, Linda Young, Young, L., Duncan, Eilidh M, Eldridge, S, Young, L, Torgerson, C, Ramsay, Craig R., Tilley, C, Translation Research in a Dental Setting (TRiaDS) Research Methodology Group, Newlands, R, Eilidh M Duncan, Paula Elouafkaoui, Elouafkaoui, Paula, Craig R Ramsay, Newlands, Rumana, Elouafkaoui, P, Prior, Maria, McKee, L   +55 more
core   +2 more sources

Antimicrobial Stewardship in Cardiac Device Surgery: Impact of Behavioural Change Interventions on Extended Prophylaxis Practices

Antibiotics
Background/Objectives: Single-dose pre-operative antibiotic prophylaxis for cardiac-device implantation is recommended but extending antibiotic prophylaxis is common.
Li Wen Loo, Yvonne Peijun Zhou, Yi Bo Wang, Lai Wei Lee, Jasmine Shimin Chung   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A Bayesian Belief Network to Infer Incentive Mechanisms to Reduce Antibiotic Use in Livestock Production [PDF]

Efficient policy intervention to reduce antibiotic use in livestock production requires knowledge about the rationale underlying antibiotic usage. Animal health status and management quality are considered the two most important factors that influence ...
Bergevoet, Ron H.M., Ge, Lan, Valeeva, Natasha I., Van Asseldonk, Marcel A.P.M., Hennen, Wil   +4 more
core  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Irrational use of antibiotics in the Moshi Municipality Northern Tanzania: a cross sectional study

The Pan African Medical Journal, 2018
INTRODUCTION: Irrational use of antibiotics includes prescription of incorrect doses, self-medication and treatment of non-bacterial illness. As a direct consequence of irrational antibiotic use, resistance to the commonly available antibiotics has been ...
Erick Alexander Mboya, Leah Anku Sanga, James Samwel Ngocho   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source