Results 111 to 120 of about 855,762 (278)

Bifurcation analysis and global dynamics of a mathematical model of antibiotic resistance in hospitals [PDF]

arXiv, 2016
Antibiotic-resistant bacteria has posed a grave threat to public health by causing a number of nosocomial infections in hospitals. Mathematical models have been used to study the transmission of antibiotic-resistant bacteria within a hospital and the measures to control antibiotic resistance in nosocomial pathogens.
arxiv  

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Advanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin   +9 more
wiley   +1 more source

Computational and AI‐Driven Design of Hydrogels for Bioelectronic Applications

Advanced Electronic Materials, EarlyView.
This review highlights the role of AI in advancing hydrogel design for bioelectronics, exploring natural, and synthetic gels tailored for applications like wound healing, biosensing, and tissue engineering. It emphasizes the synergy between hydrogels, electronics, and AI in creating responsive, multifunctional systems, showcasing recent innovations ...
Rebekah Finster, Prashant Sankaran, Eloise Bihar   +2 more
wiley   +1 more source

Photoisomerization of Azobenzene‐Extended Charybdotoxin for the Optical Control of Kv1.2 Potassium Channel Activity

Angewandte Chemie, EarlyView.
Click‐chemistry compatible azobenzenes are synthesized and coupled on various positions at the surface of a disulfide‐bridged natural peptide. Monomers and dimers are produced and linked by azobenzene. The impact of azobenzene photoswitching on the ion channel blocking potency of the peptide is evaluated and revealed that proper positioning leads to ...
Yanis Achouba, Basile Peres, Steven Ascoët, Hervé Meudal, Cécile Caumes, Claude Zoukimian, Hugo Millet, Maureen Choteau‐Bodor, Cathy Carvalhosa, Mikael Croyal, Fella Bouchama, Heike Wulff, Stéphane Téletchéa, Rémy Béroud, Eléna Ishow, Céline Landon, Ahcène Boumendjel, Jérôme Montnach, Michel De Waard   +18 more
wiley   +2 more sources

Reliable uncertainty estimate for antibiotic resistance classification with Stochastic Gradient Langevin Dynamics [PDF]

arXiv, 2018
Antibiotic resistance monitoring is of paramount importance in the face of this on-going global epidemic. Deep learning models trained with traditional optimization algorithms (e.g. Adam, SGD) provide poor posterior estimates when tested against out-of-distribution (OoD) antibiotic resistant/non-resistant genes.
arxiv  

Induction of sister chromatid exchanges by streptonigrin, an antibiotic and antineoplastic agent

Hereditas, 2009
The frequencies of chromosomal aberrations and sister chromatid exchanges, SCE, were analyzed in lateral root-tip cells of Vicia faba treated with the antibiotics streptonigrin or bleomycin. Whereas both agents were very potent inducers of chromosomal aberrations in all phases of the cell cycle, only streptonigrin was able to increase the frequency of ...
openaire   +2 more sources

Electrochemical Determination of Gallic Acid in Tea Samples Using Pyramidal Pt Nanoparticles

Advanced Electronic Materials, EarlyView.
A novel electrochemical sensor based on pyramidal Pt nanoparticles for gallic acid detection in black and green tea samples is developed. The sensor is prepared by a simple drop casting of nanoparticles on the electrode surface, without any supporting materials, such as polymer matrices and surfactants.
Tiziano Di Giulio, Maria Antonieta Ramírez‐Morales, Valentina Mastronardi, Giuseppe Mele, Rosaria Brescia, Pier Paolo Pompa, Cosimino Malitesta, Giuseppe Egidio De Benedetto, Mauro Moglianetti, Maria Ada Malvindi, Elisabetta Mazzotta   +10 more
wiley   +1 more source

Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation

Angewandte Chemie, EarlyView.
A pangenome analysis of the plant pathogen Pseudomonas syringae reveals two novel natural product families that facilitate niche adaptation. Comprehensive genomic and chemical analyses uncover unique biosynthetic gene clusters linked to host specificity and environmental fitness.
Shuaibing Zhang, Ying Huang, Raed Nachawati, Philipp Huber, Grit Walther, Lucas Gregor, Ivan Vilotijević, Pierre Stallforth   +7 more
wiley   +2 more sources

Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis

Chemistry – A European Journal, Volume 28, Issue 70, December 15, 2022., 2022
Innovative Au(I) and Ag(I) NHC‐based selenourea complexes exhibit a prominent anticancer effect by selectively targeting TrxR in human cancer cells, thus hampering cancer cell redox machinery and inducing apoptotic cell death. Abstract A series of NHC‐based selenourea Ag(I) and Au(I) complexes were evaluated for their anticancer potential in vitro, on ...
Michele De Franco, Marina Saab, Marina Porchia, Cristina Marzano, Steven P. Nolan, Fady Nahra, Kristof Van Hecke, Valentina Gandin   +7 more
wiley   +1 more source

Causes of Drug-Induced Severe Cutaneous Adverse Reaction Epidermal Necrolysis (EN): An Analysis Using FDA Adverse Event Reporting System (FAERS) Database

Clinical, Cosmetic and Investigational Dermatology, 2023
Weiqiang Fei,1 Jun Shen,2 Hui Cai3 1College of Nursing, Hangzhou Vocational & Technical College, Hangzhou, Zhejiang Province, People’s Republic of China; 2Nursing Department, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine,
Fei W, Shen J, Cai H
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