Results 111 to 120 of about 338,615 (308)

Functional foods and bioactive compounds: a comprehensive review on their role in mitigating drug-induced liver injury

Frontiers in Nutrition
Drug-induced liver injury (DILI) has become a serious public health issue worldwide. Many drugs (chemotherapy drugs, fever-reducing medications, nonsteroidal anti-inflammatory drugs, immunosuppressants, antibiotics, antivirals, and antineoplastic drugs ...
Jin-Wei Zhao, Wei-Yi Zhao, Meng Zhao, Lu Yu   +3 more
doaj   +1 more source

Alternate Strategies for Managing Resistance to Antibiotics and Pesticides [PDF]

How should one manage the problem of resistance to antibiotics and pesticides? Although the salience of this question has now been recognized, the formal modeling of this question is very much in its infancy.
Peter Nijkamp, Amit Batabyal
core  

The Trend of the Antibiotics Used at the Ohu University Dental Hospital in Years of 2000 to 2002 [PDF]

, 2004
P(論文)The authors investigated which antibiotics were used in the Ohu University Dental Hospital for the three years from 2000 to 2002. 1. The oral antibiotics which were used a lot were Varacillin (LAPC), Flomox (CFPN-PI), and Clarith (CAM). 2.
浜田, 節男, 8398, 8399, 8396, 8397, 長谷川, 淳子, 8390, 大野, 敬, 8391, HASHIMOTO, Minoru, KOKUBUN, Mihoko, 8394, 8395, 8392, 8393, 中葉, 利男, イワタ, キョウイチ, ナカハ, トシオ, 国分, 美保子, コクブン, ミホコ, ハシモト, ミノル, 8406, 8407, 8404, 8405, 岩田, 教一, HASEGAWA, Junko, 8387, 8388, 8385, 8386, HAMADA, Setsuo, ハマダ, セツオ, 8402, オオノ, タカシ, 8403, 8389, 8400, 8401, OHNO, Takashi, 8384, NAKAHA, Toshio, KAGEYAMA, Toshio, ハセガワ, ジュンコ, カゲヤマ, トシオ, 影山, 利夫, 橋本, 稔, IWATA, Kyoichi   +47 more
core  

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Applying psychological theory to evidence-based clinical practice : identifying factors predictive of managing upper respiratory tract infections without antibiotics [PDF]

, 2007
Background: Psychological models can be used to understand and predict behaviour in a wide range of settings. However, they have not been consistently applied to health professional behaviours, and the contribution of differing theories is not clear. The
Glidewell, Liz, Grimshaw, Jeremy, Johnston, Marie, Eccles, Martin P., Thomas, Ruth Elizabeth, Steen, Nick, MacLennan, Graeme Stewart, Bonetti, Debbie, Pitts, Nigel, Walker, Anne   +9 more
core   +1 more source

Antineoplastic agents; occupational hazards in hospitals

"Antineoplastic agents are widely used in cancer therapy because they can inhibit growth by disrupting cell division and killing actively growing cells. These agents can also cause health effects among health care workers who work with them. A summary of

core  

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Which antibiotics should I use?

, 2015
“Which antibiotic should I use?” It’s a question we ask ourselves when we want to initiate antibiotic treatment for our patients. When patients approach us at the clinic or hospital with fever or other symptoms of infection, they hope that they will be ...
Shalihin, Mohd Shaiful Ehsan
core  

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies

Biomedicines
Background: Tyrosine kinase inhibitors (TKIs) are crucial to treating endocrine-related malignancies, including advanced thyroid cancers and neuroendocrine tumors, but their benefit is tempered by cutaneous adverse events (CAEs) that impair adherence and
Marta Marino, Francois Rosset, Alice Nervo, Alessandro Piovesan, Valentina Pala, Elisa Vaccaro, Luca Mastorino, Aldo E. Calogero, Emanuela Arvat   +8 more
doaj   +1 more source