Results 131 to 140 of about 855,762 (278)

Radiosensitization of calreticulin‐overexpressing human glioma cell line by the polyphenolic acetate 7, 8‐diacetoxy‐4‐methylcoumarin

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background Calreticulin (CRT), an endoplasmic reticulum–resident protein generally overexpressed in cancer cells, is associated with radiation resistance. CRT shows higher transacetylase activity, as shown by us earlier, in the presence of the polyphenolic acetates (like 7, 8‐diacetoxy‐4‐methylcoumarin, DAMC) and modifies the activity of a ...
Amit Verma, Aastha Arora, Anant N Bhatt, Mohan B Arya, Ashok K Prasad, Virinder S Parmar, Bilikere S Dwarakanath   +6 more
wiley   +1 more source

Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother.
Fabia de Oliveira Andrade, Vivek Verma, Leena Hilakivi‐Clarke   +2 more
wiley   +1 more source

Self Cycloaddition of o‐Naphthoquinone Nitrosomethide to (±) Spiro{naphthalene(naphthopyranofurazan)}‐one Oxide: An Insight into its Formation

ChemPlusChem, Volume 87, Issue 12, December 2022., 2022
2‐Hydroxy‐1‐naphthaldehyde oxime was oxidized by a D−A type self cycloaddition to spiro compound. Free reaction energy is calculated at −82.0 kcal/mol indicating its predominance over the intramolecular cyclization of −37.6 kcal/mol. 8‐methoxy substituted oxime is sterically guided to 9‐methoxynaphtho[1,2‐d] instead of spiro adduct resulting to the ...
Demeter Tzeli, Ioannis E. Gerontitis, Ioannis D. Petsalakis, Petros G. Tsoungas, George Varvounis   +4 more
wiley   +1 more source

Investigation of antibacterial and anticancer activities of biosynthesized metal‐doped and undoped zinc oxide nanoparticles

Biotechnology and Applied Biochemistry, EarlyView.
Abstract Over the past 10 years, nanotechnology has emerged as a very promising technique for a wide range of biomedical applications. Green synthesized metal and metal oxide nanoparticles (NPs) are cheap, easy to produce in large quantities, and safe for the environment.
Kaan Şendal, Mahmure Üstün Özgür, Ebru Ortadoğulu Sucu, Melike Başak Findik, Ömer Erdoğan, Erman Oryaşin, Özge Çevik   +6 more
wiley   +1 more source

Design and Synthesis of Triazole‐Based p‐tert‐Butylcalix[4]Arene Conjugates and Evaluation of Their Antimicrobial, Antibiofilm, and Anti‐Quorum‐Sensing Activities

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Macrocyclic calix[n]arenes have many applications, with diverse structures that can easily be functionalized either on upper or lower rims, mostly to impart solubility and improve biological activities. In this study, triazole‐based p‐tert‐butylcalix[4]arene conjugates (AT10a and AT10b) and their p‐tert‐butylphenol analogs (AT10b and AT11b ...
Alfred Ngenge Tamfu, Selahattin Bozkurt, Ozgur Ceylan   +2 more
wiley   +1 more source

A cytotoxic survey on 2‐amino‐1H‐imidazol based synthetic marine sponge alkaloid analogues

Drug Development Research, Volume 83, Issue 8, Page 1906-1922, December 2022., 2022
Abstract Here, we describe the synthesis and biologic activity evaluation of 20 novel synthetic marine sponge alkaloid analogues with 2‐amino‐1H‐imidazol (2‐AI) core. Cytotoxicity was tested on murine 4T1 breast cancer, A549 human lung cancer, and HL‐60 human myeloid leukemia cells by the resazurin assay.
Nikolett Gémes, Zsófia Makra, Patrícia Neuperger, Enikő Szabó, József Á. Balog, Lili Borbála Flink, Beáta Kari, László Hackler Jr, László. G. Puskás, Iván Kanizsai, Gábor J. Szebeni   +10 more
wiley   +1 more source

Acute cardiovascular effects associated with the use of prescription medications: A Danish nationwide screening study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods This Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE),
Saad Hanif Abbasi, Lars Christian Lund, Jesper Hallas, Martin Thomsen Ernst, Anton Pottegård   +4 more
wiley   +1 more source

Electrode‐supported and free‐standing bilayer lipid membranes: Formation and uses in molecular electrochemistry

Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract This short review is aimed at emphasizing the recent most prominent advances in the electrochemical investigation of the interactions of molecules with purely lipid bilayers. The first part which deals with electrode‐supported bilayer lipid membranes is articulated around the nature of electrode material with a focus on mercury to celebrate ...
Eric Labbé, Olivier Buriez
wiley   +1 more source

Ultra-rapid, Quantitative, Label-free Antibiotic Susceptibility Testing via Optically Detected Purine Metabolites [PDF]

arXiv
There is an urgent need for the development of novel and truly rapid (equal or less than 1 hour) antibiotic susceptibility testing (AST) platforms in order to provide best antimicrobial prescribing practices and to help reduce the increasing global threat of antibiotic resistance.
arxiv  

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source