Results 181 to 190 of about 855,762 (278)

Impact of Octahedral Aluminum Sites on Guest Molecule Adsorption in Zeolites: A Computational Study of 5‐Fluorouracil in Zeolite FAU

Chemistry – A European Journal, EarlyView.
Dispersion‐corrected density functional theory (DFT) calculations shed light on the interaction of the anticancer drug 5‐fluorouracil (5‐FU) with a framework‐associated octahedral aluminum site in a FAU‐type zeolite. The calculations help to explain the experimental observation of a limited 5‐FU release from zeolite samples containing such sites ...
Michael Fischer
wiley   +1 more source

Analysis of the relationship between antineoplastic drugs and suicide-related adverse events based on the food and drug administration adverse event reporting system database. [PDF]

SAGE Open Med
Zhao N, Wang H, Xu H, Tang X, Cao D.
europepmc   +1 more source

Optimal Primary Prophylaxis for Febrile Neutropenia During Neoadjuvant Cisplatin and 5-Fluorouracil Plus Docetaxel for Esophageal Cancer: A Retrospective Cohort Study. [PDF]

Cancer Med
Kumanishi R, Taniguchi H, Nakazawa T, Ogata T, Matsubara Y, Kodama H, Nakata A, Honda K, Masuishi T, Narita Y, Kadowaki S, Ando M, Tajika M, Abe T, Muro K.   +14 more
europepmc   +1 more source

Anthracycline Antineoplastic Antibiotic [PDF]

, 2020
openaire   +1 more source

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, EarlyView.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source

Impact of concomitant medications on the oncologic efficacy of systemic therapy in patients with advanced or metastatic urothelial carcinoma: a systematic review and meta-analysis. [PDF]

BMC Urol
Tsuboi I, Matsukawa A, Parizi MK, Miszczyk M, Fazekas T, Schulz RJ, Laukhtina E, Kawada T, Katayama S, Iwata T, Bekku K, Rajwa P, Wada K, Oberneder K, Chlosta P, Karakiewicz PI, Araki M, Shariat SF.   +17 more
europepmc   +1 more source

Metal‐Catalyzed Cross‐Coupling for the Synthesis of β‐Lactam Drugs and Related Chemical Probes

ChemMedChem, EarlyView.
This review focus on the use of transition metal cross‐coupling strategies for the synthesis of beta‐lactam derivatives. This manuscript encompasses the seminal studies for the synthesis of antibiotics up to the current need of accessing specific probes that are crucial for the detection of resistances.
Jules Bresson, Katie Burke, Mélanie Ethève‐Quelquejeu, Laura Iannazzo, Kevin Cariou   +4 more
wiley   +1 more source

Assessing the risk of tumor lysis syndrome associated with the use of antineoplastic agents: a real-world pharmacovigilance study based on the FDA Adverse Event Reporting System database. [PDF]

Ther Adv Drug Saf
Li D, Qin C, Wang H, Du D, Wang Y, Du Q, Liu S.   +6 more
europepmc   +1 more source

Systematic Review on 1,2,3‐Oxadiazoles, 1,2,4‐Oxadiazoles, and 1,2,5‐Oxadiazoles in the Antimycobacterial Drug Discovery

ChemMedChem, EarlyView.
The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source